Evidence map›Paper›PMID 33109338›Full record

ArticleBiological psychiatry2021

Multivariate Patterns of Brain-Behavior-Environment Associations in the Adolescent Brain and Cognitive Development Study.

Amirhossein Modabbernia, Delfina Janiri, Gaelle E Doucet, Abraham Reichenberg, Sophia Frangou

Open access · bronzeAbstract read
In one paragraph

Article in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 82 citations in OpenAlex.

  1. Review
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  4. Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026
    Review
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  11. Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  12. Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Amirhossein ModabberniaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Delfina JaniriDepartment of Psychiatry and Neurology, Sapienza University of Rome, Rome, Italy.
Gaelle E DoucetBoys Town National Research Hospital, Omaha, Nebraska.
Abraham ReichenbergDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York; Seaver Center for Autism Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, New York; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Sophia FrangouDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Djavad Mowafaghian Centre for Brain Health, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: sophia.frangou@mssm.edu.
Boys Town National Research Hospital · USChild Health and Development Institute · USIcahn School of Medicine at Mount Sinai · USSapienza University of Rome · ITUniversity of British Columbia · CA

Funding

ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
Translational Imaging and Behavioral Assessment (TIBA) CoreP20GM130447 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Anna Dunaevsky · 2020 to 2026
$20.7M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
Adolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5M
NIA NIH HHS R03 AG064001NICHD NIH HHS R01 HD098883NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIEHS NIH HHS R01 ES026904NIGMS NIH HHS P20 GM130447NIMH NIH HHS R01 MH113619NIMH NIH HHS R01 MH116147
6 · The paper itself

Abstract

backgroundAdolescence is a critical developmental stage. A key challenge is to characterize how variation in adolescent brain organization relates to psychosocial and environmental influences.

methodsWe used canonical correlation analysis to discover distinct patterns of covariation between measures of brain organization (brain morphometry, intracortical myelination, white matter integrity, and resting-state functional connectivity) and individual, psychosocial, and environmental factors in a nationally representative U.S. sample of 9623 individuals (aged 9-10 years, 49% female) participating in the Adolescent Brain and Cognitive Development (ABCD) study.

resultsThese analyses identified 14 reliable modes of brain-behavior-environment covariation (canonical r

conclusionsWe identified clusters of exposures that showed consistent modality-general associations with global measures of brain organization. These findings underscore the importance of understanding the complex and intertwined influences on brain organization and mental function during development and have the potential to inform public health policies aiming toward interventions to improve mental well-being.

Indexed as

BrainWhite MatterAdolescentAdolescent DevelopmentChildCognitionFemaleHumansMagnetic Resonance ImagingMaleMental HealthABCD studyAdolescenceEnvironmentNeurodevelopmentNeuroimagingPsychopathology

Identifiers

PMID33109338
PMCPMC7867576
OpenAlexW3080606572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.