Trial reportTrials2020
The effects of exercise training on hypothalamic-pituitary-adrenal axis reactivity and autonomic response to acute stress-a randomized controlled study.
Trial report in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02051127 (Sustainable Working Life With Reduced Stress Levels - The Effects of Physical Training on Physiological and Psychological Stress-reactions and Cognitive Function.), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sustainable Working Life With Reduced Stress Levels - The Effects of Physical Training on Physiological and Psychological Stress-reactions and Cognitive Function.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Pooled it
- Exercise training improves blood pressure reactivity to stress: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- The Effects of a Single Vagus Nerve's Neurodynamics on Heart Rate Variability in Chronic Stress: A Randomized Controlled Trial.Sensors (Basel, Switzerland) · 2024Trial
- Physiological Basis of Sex Differences in Human Performance and Exercise-Associated Pathology.Clinical endocrinology · 2026Review
- Article
- The health diet as a mediator in relationship between stress and sleep quality of college students with physical exercise as a moderator.BMC pediatrics · 2026Article
- The Influence of Exercise on the Endocrine System: Impacts on Adolescent Growth and Development.Advances in experimental medicine and biology · 2026Review
- Are Team Sports Effective in Improving Mental Health? A Systematic Review on the Primary Outcomes of Anxiety and Mood.Clinical practice and epidemiology in mental health : CP & EMH · 2026Review
- Associations of physical activity and sedentary behavior with mental health among university students: the mediating role of cardiorespiratory fitness and moderating role of gender.BMC public health · 2025Article
- Anxiety and sleep hygiene among college students, a moderated mediating model.BMC public health · 2025Article
- The effect of two types of exercise conditioning on hypothalamic corticotropin-releasing hormone (CRH) and gonadotropin-releasing hormone (GNRH) gene expression response to acute noise stress in rats.BMC research notes · 2025Article
- Non-pharmacological therapeutic paradigms in stress-induced depression: from novel therapeutic perspective with focus on cell-based strategies.Acta neuropsychiatrica · 2025Review
- Stress buffering effects of physical activity in adolescents: the moderating role of physical activity attitudes.BMC public health · 2025Article
- The impact of physical activity and dietary behavior on depression in college students: a study on mediation effects and network analysis.Frontiers in public health · 2025Article
- The Impact of Chronic Exercise on Cognitive Function: An Overview of Reviews.Iranian journal of psychiatry · 2024Review
- Move the night way: how can physical activity facilitate adaptation to shift work?Communications biology · 2024Review
- The Relationship between Psychological Stress and Emotional State in Chinese University Students during COVID-19: The Moderating Role of Physical Exercise.Healthcare (Basel, Switzerland) · 2023Article
- Coping Strategies and Perceiving Stress among Athletes during Different Waves of the COVID-19 Pandemic-Data from Poland, Romania, and Slovakia.Healthcare (Basel, Switzerland) · 2022Article
- Article
- The use of coping strategies "shift-persist" mediates associations between physical activity and mental health problems in adolescents: a cross-sectional study.BMC public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExercise training is suggested to have a stress-buffering effect on physiological reactions to acute stress. The so-called cross-stressor adaptation hypothesis is one of many theories behind the plausible effects, proposing that the attenuated physiological reaction seen in trained individuals in response to acute exercise is also seen when the individual is exposed to acute psychosocial stress. However, few randomized controlled trials (RCT) are available in this field. Therefore, the aim of the present trial was to study the effects of a 6-month aerobic exercise intervention on the physiological response to acute laboratory stress.
methodsA two-armed RCT including untrained but healthy individuals aged 20-50 years was conducted. Assessments included a peak oxygen uptake test and a psychosocial stress test (the Trier Social Stress Test). A total of 88 participants went through both baseline and follow-up measures (48 in the intervention group and 40 in the control group) with a similar proportion of women and men (20 women and 28 men in the intervention group and 18 women and 22 men in the control group). Outcome measures were adrenocorticotrophic hormone, cortisol, systolic and diastolic blood pressure, and heart rate responses to acute psychosocial stress.
resultsOxygen uptake and time-to-exhaustion increased significantly following the intervention, while a decrease was seen in the control group. The analyses showed attenuated responses to acute psychosocial stress for all variables in both groups at follow-up, with no differences between the groups. No correlation was seen between amount of exercise training and reactivity to the stress test. Despite the increased oxygen uptake in the intervention group, no differences were seen between the groups for any of the outcome variables at follow-up.
conclusionsIn this study, the cross-stressor adaptation hypothesis could not be confirmed. Both groups showed decreased reactions indicating a habituation to the stress test.
trial registrationClinicalTrials.gov NCT02051127 . Registered on 31 January 2014-retrospectively registered.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.