ArticleBiology of sex differences2020
Sex differences in fatigability after ischemic preconditioning of non-exercising limbs.
Article in Biology of sex differences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- The effects of ischemic preconditioning and placebo maneuvers are similar during arm-cranking performance in upper-body trained athletes.European journal of applied physiology · 2026Trial
- Acute hypoalgesic and neurophysiological responses to lower-limb ischaemic preconditioning.Experimental brain research · 2025Trial
- Effect of Ischemic Preconditioning on Endurance Running Performance in the Heat.Journal of sports science & medicine · 2024Trial
- Enhancing physical performance with ischemic preconditioning: a systematic review and meta-analysis of moderators and performance outcomes.Biology of sport · 2026Review
- Potential Short- and Long-Term Physiological Effects of Ischemic Preconditioning as an Ergogenic Aid: Revisiting Foundational Mechanisms and Applications.Sports medicine (Auckland, N.Z.) · 2025Review
- Determining minimum cuff pressure required to reduce arterial blood flow at rest.Scientific reports · 2025Article
- Eccentric exercise-induced muscle weakness abolishes sex differences in fatigability during sustained submaximal isometric contractions.Journal of sport and health science · 2023Article
- Attenuation of Neuromuscular Fatigue by Ischemic Preconditioning with Moderate Cuff Pressure is Not Related to Muscle Oxygen Saturation in Men.International journal of exercise science · 2023Article
- Sex differences in endurance exercise capacity and skeletal muscle lipid metabolism in mice.Physiological reports · 2022Article
- Potential physiological responses contributing to the ergogenic effects of acute ischemic preconditioning during exercise: A narrative review.Frontiers in physiology · 2022Review
- Methodological Variations Contributing to Heterogenous Ergogenic Responses to Ischemic Preconditioning.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIschemic preconditioning (IPC) is suggested to decrease fatigability in some individuals but not others. Sex differences in response to IPC may account for this variability and few studies systematically investigated the effects of IPC in men and women. The goal of this study was to determine if time to task failure, perception of pain, and neuromuscular mechanisms of fatigability were altered by IPC in men and women.
methodsTen women (29 ± 5 years old) and 10 men (28 ± 6 years old) performed isometric contractions with the plantar flexor muscles of the dominant leg at 20% of maximal voluntary contraction until task failure. We used a repeated measures design where each individual performed 3 randomized and counterbalanced test sessions: (A) IPC session, cuff inflation and deflation (5 min each repeated 3 times) performed before the exercise by inflating cuffs to the non-dominant leg and arm; (B) sham session, cuffs were inflated for a short period (1 min); and (C) control session, no cuffs were involved.
resultsCompared with control, IPC increased time to task failure in men (mean difference, 5 min; confidence interval (CI) of mean difference, 2.2; 7.8 min; P = 0.01) but not women (mean difference, - 0.6 min; CI of mean difference, - 3.5; 2.4 min; P = 0.51). In men, but not women, the IPC-induced increase in time to task failure was associated with lower response to pressure pain (r = - 0.79). IPC further exposed sex differences in arterial pressure during fatiguing contractions (session × sex: P < 0.05). Voluntary activation, estimated with the twitch interpolation technique, and presynaptic inhibition of leg Ia afferents were not altered after IPC for men and women. The tested variables were not altered with sham.
conclusionsThe ergogenic effect of IPC on time to task failure was observed only in men and it was associated with reductions in the perception of pain. This pilot data suggest the previously reported inter-individual variability in exercise-induced fatigability after IPC could be a consequence of the sex and individual response to pain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.