Evidence map›Paper›PMID 33109234›Full record

ArticleScandinavian journal of trauma, resuscitation and emergency medicine2020

Exploiting an early warning Nomogram for predicting the risk of ICU admission in patients with COVID-19: a multi-center study in China.

Yiwu Zhou, Yanqi He, Huan Yang, He Yu, Ting Wang, Zhu Chen, Rong Yao, Zongan Liang

Abstract readMulticenter Study
In one paragraph

Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  6. Comparing machine learning algorithms for predicting COVID-19 mortality.BMC medical informatics and decision making · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiwu ZhouDepartment of Emergency Medicine, Emergency Medical Laboratory, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Yanqi HeDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No.37 Guoxue Roud, Chengdu, 610041, Sichuan, China.
Huan YangDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No.37 Guoxue Roud, Chengdu, 610041, Sichuan, China.
He YuDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No.37 Guoxue Roud, Chengdu, 610041, Sichuan, China.
Ting WangDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No.37 Guoxue Roud, Chengdu, 610041, Sichuan, China.
Zhu ChenPublic Health Clinical Center of Chengdu, Chengdu, 610000, China.
Rong YaoDepartment of Emergency Medicine, Emergency Medical Laboratory, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. yaorong@wchscu.cn.ORCID http://orcid.org/0000-0001-9086-255X
Zongan LiangDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No.37 Guoxue Roud, Chengdu, 610041, Sichuan, China. liang.zongan@163.com.

Funding

Science and Technology Benefit People Project of Chengdu Municipality 2016-HM02-00099-SFSpecial Funds for COVID-19 Prevention and Control of West China Hospital of Sichuan University HX-2019-nCoV-068the Emergency Response Project for New Coronavirus of Science and Technology Department of Sichuan Provincial 2020YFS0005the Emergency Response Project for New Coronavirus of Science and Technology Department of Sichuan Provincial 2020YFS0009
6 · The paper itself

Abstract

backgroundNovel coronavirus disease 2019 (COVID-19) is a global public health emergency. Here, we developed and validated a practical model based on the data from a multi-center cohort in China for early identification and prediction of which patients will be admitted to the intensive care unit (ICU).

methodsData of 1087 patients with laboratory-confirmed COVID-19 were collected from 49 sites between January 2 and February 28, 2020, in Sichuan and Wuhan. Patients were randomly categorized into the training and validation cohorts (7:3). The least absolute shrinkage and selection operator and logistic regression analyzes were used to develop the nomogram. The performance of the nomogram was evaluated for the C-index, calibration, discrimination, and clinical usefulness. Further, the nomogram was externally validated in a different cohort.

resultsThe individualized prediction nomogram included 6 predictors: age, respiratory rate, systolic blood pressure, smoking status, fever, and chronic kidney disease. The model demonstrated a high discriminative ability in the training cohort (C-index = 0.829), which was confirmed in the external validation cohort (C-index = 0.776). In addition, the calibration plots confirmed good concordance for predicting the risk of ICU admission. Decision curve analysis revealed that the prediction nomogram was clinically useful.

conclusionWe established an early prediction model incorporating clinical characteristics that could be quickly obtained on hospital admission, even in community health centers. This model can be conveniently used to predict the individual risk for ICU admission of patients with COVID-19 and optimize the use of limited resources.

Indexed as

BetacoronavirusHospitalizationIntensive Care UnitsAdultAgedChinaCoronavirus InfectionsCOVID-19FemaleHumansLogistic ModelsMaleMiddle AgedNomogramsPandemicsPneumonia, ViralCoronavirus disease 2019Early warningICU admissionNomogramPrediction

Identifiers

PMID33109234
PMCPMC7590555

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.