Evidence map›Paper›PMID 33109179›Full record

ArticleBMC veterinary research2020

Isolation and characterization of Uropathogenic Escherichia coli (UPEC) from red panda (Ailurus fulgens).

Songrui Liu, Yunli Li, Chanjuan Yue, Dongsheng Zhang, Xiaoyan Su, Xia Yan, Kuixing Yang, Xin Chen, Guifu Zhuo, Tong Cai and 3 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Songrui LiuChengdu Research Base of Giant Panda Breeding, Chengdu, 610081, Sichuan, China.
Yunli LiChengdu Research Base of Giant Panda Breeding, Chengdu, 610081, Sichuan, China.
Chanjuan YueChengdu Research Base of Giant Panda Breeding, Chengdu, 610081, Sichuan, China.
Dongsheng ZhangChengdu Research Base of Giant Panda Breeding, Chengdu, 610081, Sichuan, China.
Xiaoyan SuChengdu Research Base of Giant Panda Breeding, Chengdu, 610081, Sichuan, China.
Xia YanChengdu Research Base of Giant Panda Breeding, Chengdu, 610081, Sichuan, China.
Kuixing YangChengdu Research Base of Giant Panda Breeding, Chengdu, 610081, Sichuan, China.
Xin ChenChengdu Research Base of Giant Panda Breeding, Chengdu, 610081, Sichuan, China.
Guifu ZhuoChengdu Research Base of Giant Panda Breeding, Chengdu, 610081, Sichuan, China.
Tong CaiKey Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), Nanchong, 637009, Sichuan, China.
Jiangfeng LiuKey Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), Nanchong, 637009, Sichuan, China.
Xi PengKey Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), Nanchong, 637009, Sichuan, China. pengxi197313@163.com.
Rong HouChengdu Research Base of Giant Panda Breeding, Chengdu, 610081, Sichuan, China. 405536517@qq.com.
Chengdu Research Base of Giant Panda Breeding · CNChina West Normal University · CN

Funding

the Science and Technology Department of Sichuan Province 2017JY0099
6 · The paper itself

Abstract

backgroundDisease prevention and control is a significant part in the ex-situ conservation of the endangered red panda (Ailurus fulgens), being bacterial infection is one of the most important health threats to the captive population. To date, studies about the infection caused by Escherichia coli in the red panda are scarce. This study was conducted to determine the cause of death of a captive red panda through clinical symptoms, complete blood count, biochemical analysis, pathological diagnosis and bacterial whole genome sequencing. CASE PRESENTATION: The following report describes a case of a 1.5 year old captive red panda (Ailurus fulgens) that was found lethargic and anorectic. She was moved to the quarantine area for daily treatment with 50 mg of Cefpodoxime Proxetil. During the three-day treatment, she did not eat or defecate, and then died. Clinical hematology revealed the values of neutrophils, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and blood urea nitrogen (BUN) were significantly higher. Histological analysis demonstrated major pathological damage in the kidneys, liver and lungs, characterized by hyperemia, parenchymal cell degeneration and necrosis and inflammatory cell infiltration which were predominantly neutrophilic. A bacterial strain confirmed as Escherichia coli was isolated post mortem. Whole genome sequencing of the E. coli showed the complete genome size was 4.99 Mbp. PapA, PapC, OmpA, OmpU and other virulence factors which specific to Uropathogenic Escherichia coli (UPEC) were found in the isolate. Among the virulence factors, P pili, type I pili and related factors of the iron uptake system were associated with nephrotoxicity.

conclusionThe red panda died of bacterial infection caused by an uropathogenic strain of Escherichia coli. The pathogenic mechanisms of the strain are closely related to the expression of specific virulence genes.

Indexed as

AiluridaeAnimalsAnti-Bacterial AgentsCefpodoxime ProxetilCeftizoximeEscherichia coli InfectionsFemaleGenome, BacterialUropathogenic Escherichia coliVirulence FactorsWhole Genome SequencingAnti-Bacterial AgentsCefpodoxime ProxetilCeftizoximeVirulence FactorsPathological diagnosisRed pandaUropathogenic Escherichia coli

Identifiers

PMID33109179
PMCPMC7590469
OpenAlexW3096120516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.