ArticleBMC complementary medicine and therapies2020
Xanthine oxidase inhibitory activity of a new isocoumarin obtained from Marantodes pumilum var. pumila leaves.
Article in BMC complementary medicine and therapies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Phytochemical compounds for treating hyperuricemia associated with gout: a systematic review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Authentication ofFrontiers in pharmacology · 2022Pooled it
- Optimization and chemical modification of exopolysaccharides from lactic acid bacteria: multi-functional health-promoting properties and structure-activity relationship.Archives of microbiology · 2026Article
- The mature stem of green Asparagus as a potential dietary supplement for hyperuricemia: Asparagus ameliorates hyperuricemia by regulating hepatic uric acid metabolism and renal uric acid excretion.Food chemistry: X · 2026Article
- A universal fluorescent sensing platform based on "signal switching induced by enzyme catalyzed substrate hydrolysis" for high-throughput discovery of xanthine oxidase inhibitors from traditional Chinese medicine.Frontiers in pharmacology · 2026Article
- The Pharmacological Potential ofInternational journal of molecular sciences · 2025Review
- Integrated Approach for Species Identification and Quality Analysis forPlants (Basel, Switzerland) · 2021Article
- Ethnopharmacological Survey of Traditional Chinese Medicine Pharmacy Prescriptions for Dysmenorrhea.Frontiers in pharmacology · 2021Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
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Abstract
backgroundIn traditional Malay medicine, Marantodes pumilum (Blume) Kuntze (family Primulaceae) is commonly used by women to treat parturition, flatulence, dysentery, dysmenorrhea, gonorrhea, and bone diseases. Preliminary screening of some Primulaceae species showed that they possess xanthine oxidase inhibitory activity. Thus, this study aimed to investigate the xanthine oxidase inhibitory activity of three varieties of M. pumilum and their phytochemical compounds.
methodDichloromethane, methanol, and water extracts of the leaves and roots of M. pumilum var. alata, M. pumilum var. pumila, and M. pumilum var. lanceolata were tested using an in vitro xanthine oxidase inhibitory assay. Bioassay-guided fractionation and isolation were carried out on the most active extract using chromatographic techniques. The structures of the isolated compounds were determined using spectroscopic techniques.
resultsThe most active dichloromethane extract of M. pumilum var. pumila leaves (IC
conclusionThis study suggests that the new compound 3,7-dihydroxy-5-methoxy-4,8-dimethyl-isocoumarin (1), which was isolated from the dichloromethane extract of M. pumilum var. pumila leaves, could be a potential xanthine oxidase inhibitor.
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