Evidence map›Paper›PMID 33109138›Full record

ArticleBMC public health2020

Study protocol of a cluster randomized controlled trial of strategies to increase antenatal iron and folic acid supplementation and malaria prophylaxis in rural south-central Côte d'Ivoire.

Siaka Koné, Jürg Utzinger, Nicole Probst-Hensch, Daouda Dao, Günther Fink

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMC public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04250428 (Strategies to Increase Antenatal Iron and Folic Acid Supplementation and Malaria Prophylaxis in Rural South-central Côte d'Ivoire), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04250428 naunknown statusnot on this map

Strategies to Increase Antenatal Iron and Folic Acid Supplementation and Malaria Prophylaxis in Rural South-central Côte d'Ivoire: Study Protocol of a Cluster Randomised Controlled Trial

TypeinterventionalSponsorCentre Suisse de Recherches Scientifiques en Cote d'IvoireRan2020 to 2021Enrolled720ConditionsAntenatal CareArmsDemand intervention, Supply intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Daily oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Siaka KonéCentre Suisse de Recherches Scientifiques en Côte d'Ivoires, 01 BP 1303, Abidjan 01, Côte d'Ivoire. siaka.kone@csrs.ci.ORCID http://orcid.org/0000-0002-3966-3587
Jürg UtzingerSwiss Tropical and Public Health Institute, Basel, Switzerland.
Nicole Probst-HenschSwiss Tropical and Public Health Institute, Basel, Switzerland.
Daouda DaoCentre Suisse de Recherches Scientifiques en Côte d'Ivoires, 01 BP 1303, Abidjan 01, Côte d'Ivoire.
Günther FinkSwiss Tropical and Public Health Institute, Basel, Switzerland.
Swiss Tropical and Public Health Institute · CHSwiss Centre for Scientific Research · CI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoverage of antenatal iron and folic acid supplementation (IFAS) and intermittent preventive treatment of malaria in pregnancy (IPTp) remains low in many countries. Evidence on the most effective ways to increase both IFASIPTp is mixed overall, with only few studies directly identifying cost-effective ways to increase coverage of both interventions. The proposed study aims to assess the cost, impact and relative cost-effectiveness of two complementary strategies of increasing IFAS and malaria chemoprophylaxis coverage among pregnant women relative to the current default system in a rural low-income setting of sub-Saharan Africa. METHODS/

designThis study will be carried out in the Taabo health and demographic surveillance system (HDSS) in south-central Côte d'Ivoire. This is a cluster-randomized trial targeting 720 consenting pregnant women aged ≥15 years. The 118 clusters constituting the Taabo HDSS monitoring area will be randomly allocated to one of the following three groups with equal probability: a control group, an information only group, and an information plus home delivery group. To assess the relative effectiveness of each strategy, we will conduct an endline survey within the first 2 weeks after delivery. The primary outcomes of the trial will be maternal post-partum anaemia and malaria infection. Anaemia will be assessed using HEMOCUE devices; malaria infections will be assessed using standard rapid diagnostic tests named CareStart™ Malaria Pf (HRP2) Ag RDT (Multi Kit with capped lancet and inverted cup specimen transfer device). Other outcomes will include self-reported adherence to supplementation and malaria chemoprophylaxis, as well as miscarriages, stillbirths and low birth weight deliveries. DISCUSSION: This study will assess the cost-effectiveness of two alternative strategies to increase antenatal IFAS and malaria chemoprophylaxis coverage among pregnant women in rural Côte d'Ivoire and similar settings.

trial registrationClinicalTrials.gov NCT04250428 ; Registered 31 January 2020.

Indexed as

IronMalariaAdolescentAfrica South of the SaharaCote d'IvoireDietary SupplementsFemaleFolic AcidHumansInfant, NewbornPregnancyRandomized Controlled Trials as TopicFolic AcidIronAntenatal iron and folic acid supplementationCluster randomized controlled trialCost-effectivenessHealth and demographic surveillance systemMalaria chemoprophylaxisMaternal and child health

Identifiers

PMID33109138
PMCPMC7590727
OpenAlexW3095673940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.