Evidence map›Paper›PMID 33109076›Full record

SynthesisThe journal of headache and pain2020

Migraine and sleep disorders: a systematic review.

Cindy Tiseo, Alessandro Vacca, Anton Felbush, Tamara Filimonova, Annalisa Gai, Tatyana Glazyrina, Irina Anna Hubalek, Yelena Marchenko, Lucas Hendrik Overeem, Serena Piroso and 4 more

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 6 pooled it
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 6 syntheses or guidelines pooled it, 264 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. [Efficacy analysis of anti-migraine therapy for acute low-frequency hearing loss and investigation of its mechanisms].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Treatment of Headache in Children and Adolescents with POTS.Current pain and headache reports · 2026
    Review
  20. Review

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 5 countries.

Cindy TiseoDepartment of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Alessandro VaccaHeadache Center, Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy.
Anton FelbushPain Treatment Center, OOO "Vertebra", Samara City, Russia.
Tamara FilimonovaFederal State Budget Educational Institution of Higher Education "Academician Ye. A. Vagner Perm State Medical University" of the Ministry of Healthcare of the Russian Federation, Perm, Russia.
Annalisa GaiHeadache Center, Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy.
Tatyana GlazyrinaLLC Stomat Business Company, Moscow, Russia.
Irina Anna HubalekDepartment of Neurology, Headache Center, Charité University Medicine Berlin, Berlin, Germany.
Yelena MarchenkoV. A. Almazov National Medical Research Centre, Saint-Petersburg, Russia.
Lucas Hendrik OvereemCharité - Universitätsmedizin Berlin Charité Centrum Neurologie, Neurochirurgie und Psychiatrie CC, Berlin, Germany.
Serena PirosoDepartment of Human Neurosciences, Sapienza University of Rome, Roma, Italy.
Alexander TkachevDepartment of Neurology, Neurosurgery, medical genetics, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Paolo MartellettiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Roma, Italy.
Simona SaccoDepartment of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy. simona.sacco@yahoo.com.ORCID http://orcid.org/0000-0003-0651-1939
European Headache Federation School of Advanced Studies (EHF-SAS)
Charité - Universitätsmedizin Berlin · DEUniversity of L'Aquila · ITUniversity of Turin · ITCTO Andrea Alesini · ITFederal Almazov North-West Medical Research Centre · RUPain Management Institute · USPerm State Medical Academy · RURussian Venture Company · RUSapienza University of Rome · ITSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs.The existence of a relationship between migraine and sleep disorders has been recognized from centuries by clinicians and epidemiological studies. Nevertheless, the exact nature of this association, the underlying mechanisms and interactions are complex and not completely understood. Recent biochemical and functional imaging studies identified central nervous system structures and neurotransmitters involved in the pathophysiology of migraine and also important for the regulation of normal sleep architecture, suggesting a possible causative role, in the pathogenesis of both disorders, of a dysregulation in these common nervous system pathways.This systematic review summarizes the existing data on migraine and sleep disorders with the aim to evaluate the existence of a causal relationship and to assess the presence of influencing factors. The identification of specific sleep disorders associated with migraine should induce clinicians to systematically assess their presence in migraine patients and to adopt combined treatment strategies.

Indexed as

Migraine DisordersSleep Wake DisordersHumansSleepCircadian rhythm sleep-wake disordersHeadacheInsomniaMigraineNarcolepsyParasomniasPeriodic limb movement disorderRestless leg syndromeSleep apneaSleep disorders

Identifiers

PMID33109076
PMCPMC7590682
OpenAlexW3096801904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.