Evidence map›Paper›PMID 33108719›Full record

ArticleACS chemical neuroscience2020

James A Frank, Marc-Joseph Antonini, Po-Han Chiang, Andres Canales, David B Konrad, Indie C Garwood, Gabriela Rajic, Florian Koehler, Yoel Fink, Polina Anikeeva

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Impact of C-Terminal PKC Phosphorylation on TRPC6 Current Kinetics.International journal of molecular sciences · 2025
    Article
  3. Review
  4. Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025
    Article
  5. Article
  6. Article
  7. Smart photopharmacological agents: LaVONanoscale advances · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

James A FrankResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-6705-2540
Marc-Joseph AntoniniResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Po-Han ChiangResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Andres CanalesResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
David B KonradDepartment of Pharmacy, Ludwig Maximilian University, D-81377 Munich, Germany.
Indie C GarwoodResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Gabriela RajicVollum Institute, Oregon Health & Science University, Portland, Oregon 97239, United States.
Florian KoehlerResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Yoel FinkResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Polina AnikeevaResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-6495-5197
McGovern Institute for Brain Research · USMassachusetts Institute of Technology · USLudwig-Maximilians-Universität München · DENational Yang Ming Chiao Tung University · TWOregon Health & Science University · US

Funding

Multi-Site Non-Invasive Magnetothermal Excitation and Inhibition of Deep Brain StructuresR01MH111872 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O, PRALLE, ARND · 2016 to 2019
$3.6M
Fiber Inspired Neural Probes for the Multifunctional Dynamic Brain MappingR01NS086804 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O · 2015 to 2019
$1.7M
Supplement to Neurobiological Engineering Training ProgramT32EB019940 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JASANOFF, ALAN · 2015 to 2025
$1.4M
NIBIB NIH HHS T32 EB019940NIMH NIH HHS R01 MH111872NINDS NIH HHS R01 NS086804
6 · The paper itself

Abstract

Photoswitchable ligands can add an optical switch to a target receptor or signaling cascade and enable reversible control of neural circuits. The application of this approach, termed photopharmacology, to behavioral experiments has been impeded by a lack of integrated hardware capable of delivering both light and compounds to deep brain regions in moving subjects. Here, we devise a hybrid photochemical genetic approach to target neurons using a photoswitchable agonist of the capsaicin receptor TRPV1,

Indexed as

NeuronsVentral Tegmental AreaAnimalsBehavior, AnimalConditioning, ClassicalLigandsMiceLigandscapsaicinchemical geneticsfibersneural probesPhotopharmacologyTRPV1

Identifiers

PMID33108719
PMCPMC10251749
OpenAlexW3095637976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.