Evidence map›Paper›PMID 33108710›Full record

SynthesisCancer medicine2020

The prognostic value of circRNAs for gastric cancer: A systematic review and meta-analysis.

Hui Chen, Chengtong Liang, Xuechun Wang, Yu Liu, Zhanjun Yang, Ming Shen, Chongxu Han, Chuanli Ren

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. The Emerging Role of Circular RNAs in Prostate Cancer: A Systematic Review.Frontiers in cell and developmental biology · 2021
    Pooled it
  4. Pooled it
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hui ChenGeriatric Medicine, Northern Jiangsu People's Hospital, Yangzhou, China.
Chengtong LiangDepartment of Laboratory Medicine, Clinical Medical College of Yangzhou University, Yangzhou, China.ORCID 0000-0003-3237-3269
Xuechun WangDepartment of Laboratory Medicine, Dalian Medical University, Dalian, China.
Yu LiuDepartment of Laboratory Medicine, Medical College of Yangzhou University, Yangzhou, China.
Zhanjun YangSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China.
Ming ShenSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China.
Chongxu HanDepartment of Laboratory Medicine, Clinical Medical College of Yangzhou University, Yangzhou, China.
Chuanli RenDepartment of Laboratory Medicine, Clinical Medical College of Yangzhou University, Yangzhou, China.ORCID 0000-0002-8386-3586

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer is the third leading cause of cancer-related deaths worldwide. Novel biomarkers circRNAs can play an important role in the development of gastric cancer as oncogenes or tumor suppressor genes. The purpose of this study was to clarify the relationship between the abnormal expression of multiple circRNAs and their prognostic value in gastric cancer patients through a meta-analysis. We researched articles reporting the relationship between circRNAs and the prognosis of gastric cancer published in PubMed, Cochrane, Embase, Web of Science, Wanfang, CNKI, and VIP databases before 31 December 2019. Thirty-five articles were selected for the meta-analysis, involving 3135 gastric cancer patients. The total HR values (95% CI) of OS and DFS related to highly expressed circRNAs that indicated worse prognosis were 1.83 (1.64-2.03; p < 0.001) and 1.66 (1.33-2.07; p < 0.001), respectively. The total HR (95% CI) of OS and DFS related to highly expressed circRNAs that indicated better prognosis was 0.54 (0.45-0.66; p < 0.001) and 0.58 (0.43-0.78; p < 0.001), respectively. Two panels of five circRNAs predicted a more considerable HR value (circ_0009910, hsa_circ_0000467, hsa_circ_0065149, hsa_circ_0081143, and circDLST; and circSMARCA5, circLMTK2, hsa_circ_0001017, hsa_circ_0061276, and circ-KIAA1244). The results of the meta-analysis were 2.63 (2.08-3.33; p < 0.001) and 0.39 (0.27-0.59; p < 0.001) for OS, respectively. The two panels of dysregulated circRNAs can be considered as more suitable potential prognostic tumor biomarkers in patients with gastric cancer because of their larger HR values.

Indexed as

Biomarkers, TumorDisease-Free SurvivalGene Expression Regulation, NeoplasticHumansMicroRNAsRisk AssessmentRisk FactorsStomach NeoplasmsTime FactorsBiomarkers, TumorMicroRNAscircRNAsgastric cancermeta-analysisprognosis

Identifiers

PMID33108710
PMCPMC7724307

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.