ArticlePlant biotechnology journal2021
Identification of citrus immune regulators involved in defence against Huanglongbing using a new functional screening system.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Pangenomic Approach for the Identification and Functional Characterization of Active GASA Antimicrobial Genes in Citrus Rootstocks for Resistance Breeding Against Bacterial Pathogens.Plants (Basel, Switzerland) · 2026Article
- Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses.Plant communications · 2025Review
- Exploring the biochemical and molecular mechanisms that contribute to Huanglongbing (HLB) tolerance in Citrus australis hybrids.BMC genomics · 2025Article
- Unlocking the Sublime: A Review of Native AustralianFoods (Basel, Switzerland) · 2025Review
- Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues.Plants (Basel, Switzerland) · 2025Article
- Innovative strategies for characterizing and managing huanglongbing in citrus.World journal of microbiology & biotechnology · 2024Review
- Screening Method and Antibacterial Activity of 1,3,4-Oxadiazole Sulfone Compounds against Citrus Huanglongbing.International journal of molecular sciences · 2023Article
- Huanglongbing Pandemic: Current Challenges and Emerging Management Strategies.Plants (Basel, Switzerland) · 2022Review
- Effectors from a Bacterial Vector-Borne Pathogen Exhibit Diverse Subcellular Localization, Expression Profiles, and Manipulation of Plant Defense.Molecular plant-microbe interactions : MPMI · 2022Article
- Insights into the mechanism of Huanglongbing tolerance in the Australian finger lime (Frontiers in plant science · 2022Article
- An Overview of the Mechanisms Against "Frontiers in microbiology · 2022Review
- Molecular signatures between citrus and Candidatus Liberibacter asiaticus.PLoS pathogens · 2021Review
- Identification of citrus immune regulators involved in defence against Huanglongbing using a new functional screening system.Plant biotechnology journal · 2021Article
- A stable antimicrobial peptide with dual functions of treating and preventing citrus Huanglongbing.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Huanglongbing (HLB) is the most devastating citrus disease in the world. Almost all commercial citrus varieties are susceptible to the causal bacterium, Candidatus Liberibacter asiaticus (CLas), which is transmitted by the Asian citrus psyllid (ACP). Currently, there are no effective management strategies to control HLB. HLB-tolerant traits have been reported in some citrus relatives and citrus hybrids, which offer a direct pathway for discovering natural defence regulators to combat HLB. Through comparative analysis of small RNA profiles and target gene expression between an HLB-tolerant citrus hybrid (Poncirus trifoliata × Citrus reticulata) and a susceptible citrus variety, we identified a panel of candidate defence regulators for HLB-tolerance. These regulators display similar expression patterns in another HLB-tolerant citrus relative, with a distinct genetic and geographic background, the Sydney hybrid (Microcitrus virgata). Because the functional validation of candidate regulators in tree crops is always challenging, we developed a novel rapid functional screening method, using a C. Liberibacter solanacearum (CLso)/potato psyllid/Nicotiana benthamiana interaction system to mimic the natural transmission and infection circuit of the HLB complex. When combined with efficient virus-induced gene silencing in N. benthamiana, this innovative and cost-effective screening method allows for rapid identification and functional characterization of regulators involved in plant immune responses against HLB, such as the positive regulator BRCA1-Associated Protein, and the negative regulator Vascular Associated Death Protein.
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