ArticlePediatric nephrology (Berlin, Germany)2021
Acute kidney injury in children with chronic kidney disease is associated with faster decline in kidney function.
Article in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Risk factors for chronic kidney disease progression in VACTERL-association Korean patients: a retrospective study.Childhood kidney diseases · 2026Article
- Kidney health in VACTERL association: structural vulnerability and surveillance.Childhood kidney diseases · 2026Article
- Acute kidney injury in children and adolescents admitted for pneumonia in the Philippines.Pediatric nephrology (Berlin, Germany) · 2025Article
- Progression of acute kidney injury to chronic kidney disease: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Renal function in pediatric urologic surgical patients: Insight from the National Surgical Quality Improvement Program-Pediatric cohort.Current urology · 2025Article
- Framework for Kidney Health Follow-Up Among Neonates With Critical Cardiac Disease: A Report From the Neonatal Kidney Health Consensus Workshop.Journal of the American Heart Association · 2025Review
- Lipid-lowering drugs and risk of rapid renal function decline: a mendelian randomization study.BMC medical genomics · 2024Article
- Kidney disease progression in pediatric and adult posterior urethral valves (PUV) patients.Pediatric nephrology (Berlin, Germany) · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThis study aimed to investigate the association of acute kidney injury (AKI) with change in estimated glomerular filtration rate (eGFR) in children with advanced chronic kidney disease (CKD).
methodsSingle centre, retrospective longitudinal study including all prevalent children aged 1-18 years with nondialysis CKD stages 3-5. Variables associated with CKD were analysed for their potential effect on annualised eGFR change (ΔGFR/year) following multiple regression analysis. Composite end-point including 25% reduction in eGFR or progression to kidney replacement therapy was evaluated.
resultsOf 147 children, 116 had at least 1-year follow-up in a dedicated CKD clinic with mean age 7.3 ± 4.9 years with 91 (78.4%) and 77 (66.4%) with 2- and 3-year follow-up respectively. Mean eGFR at baseline was 29.8 ± 11.9 ml/min/1.73 m
conclusionsWe report AKI in established CKD as a predictor of accelerated kidney disease progression and highlight this as an additional modifiable risk factor to reduce progression of kidney dysfunction. Graphical abstract.
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Registered trials
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