Evidence map›Paper›PMID 33108472›Full record

ArticleCancer immunology, immunotherapy : CII2021

Retinoblastoma cell-derived Twist protein promotes regulatory T cell development.

Ruishi Zhang, Yan-Nan Song, Xiaoyan Duo, Zhihong Guo, Yanhua Sun, Zhixiong Zhang, Yongtian Lu, Beiping Miao, Ping-Chang Yang, Guohui Nie

Open access · greenAbstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Retinoblastoma and Its Tumor Microenvironment.Current oncology (Toronto, Ont.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ruishi Zhang *Department of Ophthalmology, Shenzhen Secondary Hospital and First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Yan-Nan Song *Research Center of Allergy and Immunology, Shenzhen University School of Medicine, Room A7-509, Lihu Campus, 1066 Xueyuan Blvd, Shenzhen, 518055, China.
Xiaoyan DuoDepartment of Ophthalmology, Shenzhen Secondary Hospital and First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Zhihong GuoShenzhen Luohu Medical Group, Shenzhen, China.
Yanhua SunDepartment of Pathology, Shenzhen Secondary Hospital and First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Zhixiong ZhangDepartment of Pathology, Shenzhen Secondary Hospital and First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Yongtian LuDepartment of Otolaryngology, Head and Neck Surgery, Shenzhen Secondary Hospital and First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Beiping MiaoDepartment of Otolaryngology, Head and Neck Surgery, Shenzhen Secondary Hospital and First Affiliated Hospital of Shenzhen University, Shenzhen, China. miaobeiping@163.com.
Ping-Chang YangResearch Center of Allergy and Immunology, Shenzhen University School of Medicine, Room A7-509, Lihu Campus, 1066 Xueyuan Blvd, Shenzhen, 518055, China. pcy2356@szu.edu.cn.ORCID http://orcid.org/0000-0002-3738-9385
Guohui NieDepartment of Otolaryngology, Head and Neck Surgery, Shenzhen Secondary Hospital and First Affiliated Hospital of Shenzhen University, Shenzhen, China. nghui@21cn.com.
Shenzhen Second People's Hospital · CNShenzhen University · CNShenzhen Luohu People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe development of tumor tissue-infiltrating regulatory T cell (Treg) is incompletely understood. This study investigates the role of retinoblastoma cell (Rbc)-derived Twist‑related protein 1 (Twist) in the Treg development.

methodsThe surgically removed Rb tissues were collected. Rbcs were cultured with CD4

resultsWe found that more than 90% Rbcs expressed Twist. Foxp3

conclusionsRbcs express Twist, that induces IL-4

Indexed as

Biomarkers, TumorCD8-Positive T-LymphocytesCell ProliferationFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHumansMaleNuclear ProteinsPrognosisRetinal NeoplasmsRetinoblastomaRetinoblastoma ProteinT-Lymphocytes, RegulatoryTumor Cells, CulturedTumor MicroenvironmentBiomarkers, TumorNuclear ProteinsRetinoblastoma ProteinTWIST1 protein, humanTwist-Related Protein 1ApoptosisRegulatory T cellRetinoblastomaTumor toleranceTwist

Identifiers

PMID33108472
PMCPMC10992014
OpenAlexW3096974726

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.