Evidence map›Paper›PMID 33108241›Full record

ArticleBioengineered2020

Correlation in gene expression between the aggravation of chronic obstructive pulmonary disease and the occurrence of complications.

Yuchen Cai, Runhan Liu, Xinhe Lu, Qiming Zhang, Xinwei Wang, Huijing Lian, Haohua Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yuchen CaiDepartment of Mathematics, School of Science, Hainan University , Haikou, Hainan Province, China.
Runhan LiuDepartment of Mathematics, School of Science, Hainan University , Haikou, Hainan Province, China.
Xinhe LuSchool of Life and Pharmaceutical Science , Haikou, Hainan Province, China.
Qiming ZhangSchool of Electrical and Information Engineering, Anhui University of Science and Technology , Huainan, Anhui Province, China.
Xinwei WangCollege of Information Science and Engineering, Ocean University of China , Qingdao, Shandong Province, China.
Huijing LianSchool of Economics, Hainan University , Haikou, Hainan Province, China.
Haohua WangDepartment of Mathematics, School of Science, Hainan University , Haikou, Hainan Province, China.ORCID 0000-0001-7249-6672
Hainan University · CNAnhui University of Science and Technology · CNOcean University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aggravation of the chronic obstructive pulmonary disease (COPD) often leads to a slew of complications, but the correlation between COPD aggravation and the complications on the basis of molecular level remains unclear. In this study, gene expression profiles of COPD in patients at early and aggravation stages were collected and differentially-expressed genes were selected. Meanwhile, gene expression data implicated in COPD complications were analyzed to establish a regulatory network of COPD aggravation and COPD related complications. In addition, the gene enrichment function of DAVID6.7 was utilized to evaluate the similarities between COPD aggravation and COPD complications in term of biological process. By analyzing the genes of COPD aggravation and the COPD complications, we found 18 genes highly related to COPD aggravation, among which haptoglobin (HP) was correlated with 14 complications, followed by ADRB2, LCK and CA1, which were related to 13, 11 and 11 complications, respectively. As far as the complications concerned, obesity was regulated by 17 of the 18 genes, which indicated that there was a close correlation between COPD aggravation and obesity. Meanwhile, lung cancer, diabetes and heart failure were regulated by 15, 15 and 14 genes, respectively, among the 18 selected genes. This study suggested the driver genes of COPD aggravation were capable of extensively regulating COPD complications, which would provide a theoretical basis for development of cures for COPD and its complications.

Indexed as

Computational BiologyGene Expression ProfilingHaptoglobinsHumansPulmonary Disease, Chronic ObstructiveReceptors, Adrenergic, beta-2ADRB2 protein, humanHaptoglobinsReceptors, Adrenergic, beta-2bioinformaticsChronic obstructive pulmonary diseasecomplicationshared gene

Identifiers

PMID33108241
PMCPMC8291885
OpenAlexW3095601481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.