ArticleeLife2020
SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
What it found
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Who cites it
46 citing papers in PubMed, 78 citations in OpenAlex.
- Nicotinamide Mononucleotide Adenylyltransferase 1 and NADMetabolites · 2026Review
- Review
- Novel compound heterozygous variants in NMNAT1 associated with leber congenital amaurosis: clinical and mutational profiles.Molecular biology reports · 2026Article
- Anatomically Guided Non-Viral CRISPR/Cas9 Delivery in the Eye: Overcoming Barriers for Precision Gene Therapy.Pharmaceutics · 2026Review
- MKK4 and MKK7 control degeneration of retinal ganglion cell somas and axons after glaucoma-relevant injury.Cell death discovery · 2025Article
- A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia.Science advances · 2025Article
- Elucidating photoreceptor gene function with in-vivo CRISPR knock-out perturbation assay.Research square · 2025Article
- SARM1: The Checkpoint of Axonal Degeneration in the Nervous System Disorders.Molecular neurobiology · 2025Review
- Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis.Investigative ophthalmology & visual science · 2025Article
- A Role for SARM1 in Photoreceptor Cell Death.Advances in experimental medicine and biology · 2025Review
- Aging of the eye: Lessons from cataracts and age-related macular degeneration.Ageing research reviews · 2024Review
- Programmed axon death: a promising target for treating retinal and optic nerve disorders.Eye (London, England) · 2024Review
- SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease.Aging and disease · 2024Article
- Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function.JCI insight · 2024Article
- Dysregulated Arginine Metabolism Is Linked to Retinal Degeneration in Cep250 Knockout Mice.Investigative ophthalmology & visual science · 2023Article
- Expression of NMNAT1 in the photoreceptors is sufficient to preventMolecular therapy. Methods & clinical development · 2023Article
- SARM1 detection in myelinating glia:Frontiers in cellular neuroscience · 2023Article
- A duplex structure of SARM1 octamers stabilized by a new inhibitor.Cellular and molecular life sciences : CMLS · 2022Article
- Multiomic Mass Spectrometry Imaging to Advance Future Pathological Understanding of Ocular Disease.Metabolites · 2022Article
- A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model.The Journal of clinical investigation · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 2 countries.
Yo SasakiDepartment of Genetics, Washington University School of Medicine, St. Louis, United States.ORCID 0000-0003-0024-0031
Hiroki KakitaDepartment of Genetics, Washington University School of Medicine, St. Louis, United States.
Shunsuke KubotaDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, United States.
Abdoulaye SeneDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, United States.
Tae Jun LeeDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, United States.ORCID 0000-0003-2699-2573
Norimitsu BanDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, United States.
Zhenyu DongDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, United States.
Joseph B LinDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, United States.ORCID 0000-0001-6667-9018
Sanford L BoyeDepartment of Pediatrics, Powell Gene Therapy Center, Gainesville, United States.ORCID 0000-0002-8803-9369
Aaron DiAntonioDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, United States.ORCID 0000-0002-7262-0968
Shannon E BoyeDepartment of Pediatrics, Division of Cellular and Molecular Therapy, Gainesville, United States.ORCID 0000-0002-7312-3197
Rajendra S ApteDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, United States.ORCID 0000-0003-2281-2336
Jeffrey MilbrandtDepartment of Genetics, Washington University School of Medicine, St. Louis, United States.
Washington University in St. Louis · USAichi Medical University · JP
Funding
NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MPHYSIOLOGY AND GENETICS OF THE GDNF HOMOLOG NEURTURINR01AG013730 · NIA · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 1996 to 2026
$10.6MEngineering AAV for safe and efficient gene delivery to the human retinaR01EY024280 · NEI · UNIVERSITY OF FLORIDA · PI Shannon Elizabeth Boye · 2014 to 2026
$7.5MDISSECTION OF SARM1-INDUCED AXON DEGENERATION AND CELL DEATHR01NS087632 · NINDS · WASHINGTON UNIVERSITY · PI Aaron Diantonio, JEFFREY D MILBRANDT · 2014 to 2026
$6.4MTHE IMPORTANCE OF MACROPHAGE SENESCENCE IN REGULATING ANGIOGENESIS IN THE EYER01EY019287 · NEI · WASHINGTON UNIVERSITY · PI APTE, RAJENDRA S · 2010 to 2021
$3.9MRegulating NAD Metabolism to Inhibit Axon Degeneration in Neurodegenerative DiseasesRF1AG013730 · NIA · WASHINGTON UNIVERSITY · PI MILBRANDT, JEFFREY D · 2017 to 2017
$2.8M(PQ#9) Promoting Axon Stability to Prevent Therapy-induced Peripheral NeuropathyR01CA219866 · NCI · WASHINGTON UNIVERSITY · PI DIANTONIO, AARON, MILBRANDT, JEFFREY D · 2017 to 2021
$2.3MCompromised LDH activity causes motor deficits and hastens ALS progressionR56AG013730 · NIA · WASHINGTON UNIVERSITY · PI MILBRANDT, JEFFREY D · 2022 to 2022
$503kNCI NIH HHS CA219866NCI NIH HHS R01 CA219866NEI NIH HHS EY019287-06NEI NIH HHS R01 EY019287NEI NIH HHS R01 EY024280NIA NIH HHS AG013730NIA NIH HHS R01 AG013730NIA NIH HHS R56 AG013730NIA NIH HHS RF1 AG013730NIDDK NIH HHS P30 DK020579NIGMS NIH HHS T32 GM007200NINDS NIH HHS NS087632NINDS NIH HHS R01 NS087632
Abstract
Leber congenital amaurosis type nine is an autosomal recessive retinopathy caused by mutations of the NAD
Indexed as
Cell DeathAnimalsArmadillo Domain ProteinsCytoskeletal ProteinsDisease Models, AnimalFemaleHumansLeber Congenital AmaurosisMaleMiceNicotinamide-Nucleotide AdenylyltransferasePhotoreceptor Cells, VertebrateRetinal DegenerationArmadillo Domain ProteinsCytoskeletal ProteinsNicotinamide-Nucleotide AdenylyltransferaseNmnat1 protein, mouseSARM1 protein, mouseaxonal degenerationLCA9mouseNAD+neuroscienceNMNAT1retinal degenerationsSARM1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.