Evidence map›Paper›PMID 33107815›Full record

ArticleCanadian journal of surgery. Journal canadien de chirurgie

Canadian survey on the rates of use of intraoperative diuretics and justification for their use during renal allograft reperfusion.

Max A Levine, Patrick P Luke, Alp Sener

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Canadian journal of surgery. Journal canadien de chirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07726134 (A Pilot Randomized, Surgeon-blinded, Trial of Intraoperative Furosemide Versus Mannitol Among Deceased Donor Kidney Transplant Recipients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07726134 nanot yet recruitingnot on this map

A Pilot Randomized, Surgeon-blinded, Trial of Intraoperative Furosemide Versus Mannitol Among Deceased Donor Kidney Transplant Recipients

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2026 to 2028Enrolled160ConditionsDelayed Graft Function, Kidney TransplantationArmsFurosemide, Mannitol
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Max A LevineFrom the Department of Surgery (Levine, Luke, Sener); and the Department of Microbiology and Immunology (Sener), Schulich School of Medicine and Dentistry, Western University, London, Ont.; the Matthew Mailing Centre for Translational Transplant Studies (Luke, Sener); and the Multi-Organ Transplant Program (Levine, Luke, Sener), London Health Sciences Centre, University Hospital, London, Ont.
Patrick P LukeFrom the Department of Surgery (Levine, Luke, Sener); and the Department of Microbiology and Immunology (Sener), Schulich School of Medicine and Dentistry, Western University, London, Ont.; the Matthew Mailing Centre for Translational Transplant Studies (Luke, Sener); and the Multi-Organ Transplant Program (Levine, Luke, Sener), London Health Sciences Centre, University Hospital, London, Ont.
Alp SenerFrom the Department of Surgery (Levine, Luke, Sener); and the Department of Microbiology and Immunology (Sener), Schulich School of Medicine and Dentistry, Western University, London, Ont.; the Matthew Mailing Centre for Translational Transplant Studies (Luke, Sener); and the Multi-Organ Transplant Program (Levine, Luke, Sener), London Health Sciences Centre, University Hospital, London, Ont.
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMannitol and furosemide have been used as diuretics intraoperatively to facilitate early renal allograft function and reduce delayed graft function. As the evidence of any efficacy of these agents is limited, we sought to characterize the use of diuretics among transplant surgeons.

methodsAn anonymous online survey was sent to all Canadian transplant programs where kidney transplants are routinely performed. Questions were related to the use and indications for mannitol and furosemide. Responses were collected and analyzed as counts and percentages of respondents. We used χ2 analysis to assess the relationship between demographic factors and survey responses.

resultsThirty-five surgeons completed the survey (response rate 50%). Seventy per cent of respondents reported performing 26 or more transplants per year, 88% had formal transplant fellowship training and 67% indicated that they currently train fellows. Only 24% and 12% reported believing that delayed graft function is reduced by mannitol and furosemide use, respectively. However, 73% routinely gave mannitol to patients and 53% routinely gave furosemide. The most common justification given for mannitol use was to induce diuresis (54%); 37% of respondents reported using mannitol because of training dogma. Likewise, 57% used furosemide for diuresis, with 23% reporting that their use of this agent was based on dogma. No relationship emerged between fellowship training, case volume or training program status and the use of any agent. Interestingly, 71% of respondents indicated that a randomized controlled trial evaluating the utility of intraoperative diuretics is needed and that they were interested in participating in such a trial.

conclusionUse of intraoperative diuretics and the rationale for their use vary among surgeons. A substantial proportion of surgeons use these medications on the basis of dogma alone. A randomized controlled trial is needed to clarify the role of intraoperative diuretics in kidney transplant surgery.

Indexed as

AllograftsCanadaDelayed Graft FunctionDiuresisDiureticsFurosemideHumansIntraoperative CareKidneyKidney TransplantationMannitolReperfusionSurveys and QuestionnairesTreatment OutcomeDiureticsFurosemideMannitol

Identifiers

PMID33107815
PMCPMC7608697
OpenAlexW3094417723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.