Evidence map›Paper›PMID 33107623›Full record

Observational studyClinical cardiology2020

Prevalence of atrial fibrillation dependent on coronary artery status: Insights from the LIFE-Heart Study.

Jelena Kornej, Sylvia Henger, Timm Seewöster, Andrej Teren, Ralph Burkhardt, Holger Thiele, Joachim Thiery, Markus Scholz

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Clinical cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  7. Practical guide on left atrial appendage closure for the non-implanting physician: an international consensus paper.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
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  12. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Jelena KornejNational Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA.ORCID https://orcid.org/0000-0003-3551-1145
Sylvia HengerLIFE - Leipzig Research Center of Civilization Diseases, Leipzig University, Leipzig, Germany.
Timm SeewösterDepartment of Electrophysiology, Heart Center at University of Leipzig, Leipzig, Germany.ORCID https://orcid.org/0000-0002-2873-6779
Andrej TerenLIFE - Leipzig Research Center of Civilization Diseases, Leipzig University, Leipzig, Germany.
Ralph BurkhardtLIFE - Leipzig Research Center of Civilization Diseases, Leipzig University, Leipzig, Germany.
Holger ThieleDepartment of Internal Medicine/Cardiology, Heart Center at University of Leipzig, Leipzig, Germany.
Joachim ThieryLIFE - Leipzig Research Center of Civilization Diseases, Leipzig University, Leipzig, Germany.
Markus ScholzLIFE - Leipzig Research Center of Civilization Diseases, Leipzig University, Leipzig, Germany.
Leipzig University · DELeipzig Heart Institute · DEBoston University · USUniversity Hospital Regensburg · DE

Funding

European Regional Development FundH2020 Marie Sklodowska-Curie Actions 838259
6 · The paper itself

Abstract

backgroundCoronary artery disease (CAD) is a significant risk factor for atrial fibrillation (AF). Experimental studies demonstrated that atrial ischemia induced by right coronary artery (RCA) stenosis promote AF triggers and development of electro-anatomical substrate for AF.

aimTo analyze the association between AF prevalence and coronary arteries status in the LIFE-Heart Study.

methodsThis analysis included patients with available coronary catheterization data recruited between 2006 and 2014. Patients with acute myocardial infarction were excluded. CAD was defined as stenosis ≥75%, while coronary artery sclerosis (CAS) was defined as non-critical plaque(s) <75%.

resultsIn total, 3.458 patients (median age 63 years, 34% women) were included into analysis. AF was diagnosed in 238 (6.7%) patients. There were 681 (19.7%) patients with CAS and 1.411 (40.8%) with CAD (27.5% with single, 32.4% with double, and 40.1% with triple vessel CAD). In multivariable analysis, there was a significant association between prevalent AF and coronary artery status (OR 0.64, 95% CI 0.53-0.78, P

conclusionIn the LIFE-Heart Study, CAS but not CAD was associated with increased risk of AF.

Indexed as

ElectrocardiographyAgedAtrial FibrillationCardiac CatheterizationCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleGermanyHumansMaleMiddle AgedPrevalenceRetrospective StudiesRisk Factorsatrial fibrillationCAD extentCAD origincoronary artery diseasecoronary artery sclerosisprevalence

Identifiers

PMID33107623
PMCPMC7724233
OpenAlexW3093848110

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.