Evidence map›Paper›PMID 33107429›Full record

ArticleeLife2020

Drivers and sites of diversity in the DNA adenine methylomes of 93

Samuel J Modlin, Derek Conkle-Gutierrez, Calvin Kim, Scott N Mitchell, Christopher Morrissey, Brian C Weinrick, William R Jacobs, Sarah M Ramirez-Busby, Sven E Hoffner, Faramarz Valafar

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Genome-wide transcriptional landscape ofFrontiers in immunology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Widespread loss-of-function mutations implicating preexisting resistance to new or repurposed anti-tuberculosis drugs.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Heliyon · 2023
    Article
  13. Article
  14. Novel and reported compensatory mutations inFrontiers in microbiology · 2023
    Article
  15. Article
  16. Article
  17. Integration of themBio · 2022
    Article
  18. Article
  19. Multiple genetic paths including massive gene amplification allowProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. DNA Methyltransferase HsdM Induce Drug Resistance onAntibiotics (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Samuel J ModlinLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, San Diego State University, San Diego, United States.
Derek Conkle-GutierrezLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, San Diego State University, San Diego, United States.
Calvin KimLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, San Diego State University, San Diego, United States.
Scott N MitchellLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, San Diego State University, San Diego, United States.
Christopher MorrisseyLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, San Diego State University, San Diego, United States.
Brian C WeinrickTrudeau Institute, Saranac Lake, United States.
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.ORCID 0000-0003-3321-3080
Sarah M Ramirez-BusbyLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, San Diego State University, San Diego, United States.ORCID 0000-0001-7455-1903
Sven E HoffnerLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, San Diego State University, San Diego, United States.
Faramarz ValafarLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence, San Diego State University, San Diego, United States.ORCID 0000-0002-3648-9384
San Diego State University · USAlbert Einstein College of Medicine · USTrudeau Institute · US

Funding

Evolutionary and Functional Significance of Novel Mutations in MDR-XDR TBR01AI105185 · NIAID · SAN DIEGO STATE UNIVERSITY · PI VALAFAR, FARAMARZ · 2013 to 2021
$5.3M
Undetected Drug resistance and Tolerance in lesions of recurrent TBR01AI163202 · NIAID · SAN DIEGO STATE UNIVERSITY · PI VALAFAR, FARAMARZ · 2022 to 2025
$2.8M
National Institute of Allergy and Infectious Diseases R01AI105185NIAID NIH HHS R01 AI105185NIAID NIH HHS R01 AI163202
6 · The paper itself

Abstract

This study assembles DNA adenine methylomes for 93

Indexed as

DNA MethylationEpigenomeGenetic VariationAdenineMutationMycobacterium tuberculosisAdeninecomputational biologydna methylationepigeneticinfectious diseaseintercellular mosaic methylationintracellular stochastic methylationmicrobiologyphenotypic plasticitysystems biologytuberculosis

Identifiers

PMID33107429
PMCPMC7591249
OpenAlexW3093976573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.