Evidence map›Paper›PMID 33107403›Full record

ArticleThyroid : official journal of the American Thyroid Association2021

Fine-Tuning Lipid Metabolism by Targeting Mitochondria-Associated Acetyl-CoA-Carboxylase 2 in

Veronica Valvo, Asumi Iesato, Taylor R Kavanagh, Carmen Priolo, Zsuzsanna Zsengeller, Alfredo Pontecorvi, Isaac E Stillman, Suzanne D Burke, Xiaowen Liu, Carmelo Nucera

Open access · greenAbstract read
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Acetate Metabolism in Thyroid Cancer Progression.International journal of molecular sciences · 2026
    Article
  3. Article
  4. Review
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  6. Review
  7. Review
  8. Article
  9. Reprogramming of fatty acid metabolism in thyroid cancer: Potential targets and mechanisms.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. The Role of Lipid Metabolism Disorders in the Development of Thyroid Cancer.International journal of molecular sciences · 2024
    Review
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Veronica ValvoLaboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Experimental Pathology, Department of Pathology, Cancer Research Institute (CRI), Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Asumi IesatoLaboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Experimental Pathology, Department of Pathology, Cancer Research Institute (CRI), Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Taylor R KavanaghDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Carmen PrioloDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Zsuzsanna ZsengellerDepartment of Pathology; Harvard Medical School, Boston, Massachusetts, USA.
Alfredo PontecorviDepartment of Medicine, Agostino Gemelli Medical School, UCSC, Rome, Italy.
Isaac E StillmanDepartment of Pathology; Harvard Medical School, Boston, Massachusetts, USA.
Suzanne D BurkeDepartment of Medicine; Harvard Medical School, Boston, Massachusetts, USA.
Xiaowen LiuDepartment of Emergency Medicine; Harvard Medical School, Boston, Massachusetts, USA.
Carmelo NuceraLaboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Experimental Pathology, Department of Pathology, Cancer Research Institute (CRI), Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Harvard University · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USAgostino Gemelli University Polyclinic · ITBroad Institute · US

Funding

Role of newly identified, thyroid-specific LincRNA in BRAFV600E thyroid carcinomaR01CA248031 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NUCERA, CARMELO · 2020 to 2024
$2.0M
BRAFV600E and VEGFR2 synergize to trigger papillary thyroid cancer progressionR01CA181183 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NUCERA, CARMELO · 2014 to 2018
$1.8M
NCI NIH HHS R01 CA181183NCI NIH HHS R01 CA248031
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutationAcetyl-CoA CarboxylaseAnimalsAntineoplastic AgentsCell Line, TumorDatabases, GeneticDrug Resistance, NeoplasmEnergy MetabolismFatty AcidsGenetic Predisposition to DiseaseHumansLipogenesisMiceMitochondriaOxidation-ReductionPhenotypeACACB protein, humanAcetyl-CoA CarboxylaseAntineoplastic AgentsBRAF protein, humanFatty AcidsProtein Kinase InhibitorsProto-Oncogene Proteins B-rafVemurafenibACC2beta-oxidationBRAFV600E, ACC1de novo lipid synthesisfatty acid synthesismitochondriaROSseahorsevemurafenib

Identifiers

PMID33107403
PMCPMC8558082
OpenAlexW3094369981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.