ArticleInfluenza and other respiratory viruses2021
Home collection of nasal swabs for detection of influenza in the Household Influenza Vaccine Evaluation Study.
Article in Influenza and other respiratory viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Diagnostic Performance of Self-Collected Respiratory Swabs for SARS-CoV-2 and Influenza Virus in Community-Dwelling Older Adults.Influenza and other respiratory viruses · 2026Article
- The role of viral interaction in household transmission of symptomatic influenza and respiratory syncytial virus.Nature communications · 2025Article
- Molecular characterization of human respiratory syncytial virus strains circulating among hospitalized children in Jordan.BMC infectious diseases · 2024Article
- Effectiveness of Self-Collected, Ambient Temperature-Preserved Nasal Swabs Compared to Samples Collected by Trained Staff for Genotyping of Respiratory Viruses by Shotgun RNA Sequencing: Comparative Study.JMIR formative research · 2023Article
- Acceptability, Feasibility, and Validity of Detecting Respiratory Pathogens During Acute Respiratory Illness in Participant-Collected Swabs in a Low-Income, Community Sample.Open forum infectious diseases · 2023Article
- Respiratory virus circulation during the first year of the COVID-19 pandemic in the Household Influenza Vaccine Evaluation (HIVE) cohort.Influenza and other respiratory viruses · 2023Article
- Rapid transmission and tight bottlenecks constrain the evolution of highly transmissible SARS-CoV-2 variants.Nature communications · 2023Article
- Rapid transmission and tight bottlenecks constrain the evolution of highly transmissible SARS-CoV-2 variants.bioRxiv : the preprint server for biology · 2022Article
- Genomic surveillance of SARS-CoV-2 Omicron variants on a university campus.Nature communications · 2022Article
- Influenza.Lancet (London, England) · 2022Review
- TaqMan Array Card testing of participant-collected stool smears to determine the pathogen-specific epidemiology of travellers' diarrhoea†.Journal of travel medicine · 2022Article
- SARS-CoV-2 Infection in Health Care Personnel and Their Household Contacts at a Tertiary Academic Medical Center: Protocol for a Longitudinal Cohort Study.JMIR research protocols · 2021Article
- Home collection of nasal swabs for detection of influenza in the Household Influenza Vaccine Evaluation Study.Influenza and other respiratory viruses · 2021Article
- Detection of SARS-CoV-2 RNA and Antibodies in Diverse Samples: Protocol to Validate the Sufficiency of Provider-Observed, Home-Collected Blood, Saliva, and Oropharyngeal Samples.JMIR public health and surveillance · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundCommunity-based studies of influenza and other respiratory viruses (eg, SARS-CoV-2) require laboratory confirmation of infection. During the current COVID-19 pandemic, social distancing guidelines require alternative data collection in order to protect both research staff and participants. Home-collected respiratory specimens are less resource-intensive, can be collected earlier after symptom onset, and provide a low-contact means of data collection. A prospective, multi-year, community-based cohort study is an ideal setting to examine the utility of home-collected specimens for identification of influenza.
methodsWe describe the feasibility and reliability of home-collected specimens for the detection of influenza. We collected data and specimens between October 2014 and June 2017 from the Household Influenza Vaccine Evaluation (HIVE) Study. Cohort participants were asked to collect a nasal swab at home upon onset of acute respiratory illness. Research staff also collected nose and throat swab specimens in the study clinic within 7 days of onset. We estimated agreement using Cohen's kappa and calculated sensitivity and specificity of home-collected compared to staff-collected specimens.
resultsWe tested 336 paired staff- and home-collected respiratory specimens for influenza by RT-PCR; 150 staff-collected specimens were positive for influenza A/H3N2, 23 for influenza A/H1N1, 14 for influenza B/Victoria, and 31 for influenza B/Yamagata. We found moderate agreement between collection methods for influenza A/H3N2 (0.70) and B/Yamagata (0.69) and high agreement for influenza A/H1N1 (0.87) and B/Victoria (0.86). Sensitivity ranged from 78% to 86% for all influenza types and subtypes. Specificity was high for influenza A/H1N1 and both influenza B lineages with a range from 96% to 100%, and slightly lower for A/H3N2 infections (88%).
conclusionsCollection of nasal swab specimens at home is both feasible and reliable for identification of influenza virus infections.
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