Trial reportPaediatric and perinatal epidemiology2021
Adiposity is associated with anovulation independent of serum free testosterone: A prospective cohort study.
Trial report in Paediatric and perinatal epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Target trial emulation of preconception serum vitamin D status on fertility outcomes: a couples-based approach.Fertility and sterility · 2025Trial
- BMI-Dependent Correlations of Sex Hormone Genes with Simple Endometrial Hyperplasia.Life (Basel, Switzerland) · 2026Article
- Association between alpha-1-acid glycoprotein and infertility in the NHANES 2015-2020.Medicine · 2025Article
- Association between weight loss and reproductive outcomes among women with overweight or obesity: a cohort study using UK real-world data.Human reproduction (Oxford, England) · 2025Article
- Testosterone mediates life-history trade-offs in female mammals.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Influence of state-of-the-art laboratory techniques on the phenotyping of women with polycystic ovary syndrome in the clinical setting.Journal of endocrinological investigation · 2025Article
- Body Mass Index and Uterine Fibroid Development: A Prospective Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundObesity, a body mass index (BMI) ≥30 kg/m
objectiveTo characterise the associations between adiposity and anovulation among women menstruating on a regular basis.
methodsWomen from the EAGeR trial (n = 1200), a randomised controlled trial of low-dose aspirin and pregnancy loss among women trying to conceive, were used to estimate associations between adiposity and incident anovulation. Participants completed baseline questionnaires and anthropometry, and provided blood specimens. Women used fertility monitors for up to six consecutive menstrual cycles, with collection of daily first morning voids for hormone analysis in the first two menstrual cycles for prospective assessment of anovulation. Anovulation was assessed by urine pregnanediol glucuronide or luteinising hormone concentration or the fertility monitor. Weighted mixed-effects log-binomial regression was used to estimate associations between measures of adiposity and incident anovulation, adjusted for free (bioavailable) testosterone, anti-Mullerian hormone (AMH), serum lipids, and demographic and life style factors.
results343 (28.3%) women experienced at least one anovulatory cycle. Anovulation risk was higher per kg/m
conclusionsAdiposity may be associated with anovulation through pathways other than testosterone among regularly menstruating women. This may account in part for reported associations between greater adiposity and infertility among women having menstrual cycles regularly. Understanding the association between adiposity and anovulation might lead to targeted interventions for preventing infertility.
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