ArticleJournal of internal medicine2021
Cardiovascular risk factors and lifestyle behaviours in relation to longevity: a Mendelian randomization study.
Article in Journal of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Pooled it
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies.European journal of epidemiology · 2022Pooled it
- Association of m.5178C>A variant with serum lipid levels: a systematic review and meta-analysis.Bioscience reports · 2021Pooled it
- Genetically predicted education attainment in relation to somatic and mental health.Scientific reports · 2021Pooled it
- Relationships between glucose variability with white matter hyperintensity and cerebrovascular abnormalities.Archives of endocrinology and metabolism · 2026Article
- Longevity.Clinical medicine & research · 2026Review
- Assessing the causal impact of leisure-time physical activity and screen time on lifespan: a Mendelian randomization study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Article
- Triple A Plus (AAAAmerican journal of hematology · 2025Article
- Multisystemic Impact of RNF213 Arg4810Lys: A Comprehensive Review of Moyamoya Disease and Associated Vasculopathies.International journal of molecular sciences · 2025Review
- Active longevity and aging: dissecting the impacts of physical and sedentary behaviors on longevity and age acceleration.GeroScience · 2025Observational
- Ignored or underestimated - evaluation and treatment of cardiovascular risk factors in patients with adrenal insufficiency.Endocrine · 2025Article
- Visit-to-visit glucose variability is associated with echocardiographic variables in people with type 2 diabetes: epidemiological and mendelian randomization approaches.Diabetology & metabolic syndrome · 2025Article
- Evaluating the differences in healthy lifestyle behaviors between Chinese urban and rural residency after the termination of social distancing: analysis based on propensity score matching.BMC public health · 2025Article
- Genetic Liability to Cardiovascular Disease, Physical Activity, and Mortality: Findings from the Finnish Twin Cohort.Medicine and science in sports and exercise · 2024Article
- Influence of daily life and health profile in subtle cognitive decline of women residing in Spanish religious communities: DeCo religious orders study.Frontiers in public health · 2024Observational
- Selection of genetic instruments in Mendelian randomisation studies of sleep traits.Sleep medicine · 2023Review
- Effects of home visiting programmes on community-dwelling older adults with chronic multimorbidity: a scoping review.BMC nursing · 2023Article
- Mendelian randomization evidence for the causal effects of socio-economic inequality on human longevity among Europeans.Nature human behaviour · 2023Article
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe American Heart Association introduced the Life's Simple 7 initiative to improve cardiovascular health by modifying cardiovascular risk factors and lifestyle behaviours. It is unclear whether these risk factors are causally associated with longevity.
objectivesThis study aimed to investigate causal associations of Life's Simple 7 modifiable risk factors, as well as sleep and education, with longevity using the two-sample Mendelian randomization design.
methodsInstrumental variables for the modifiable risk factors were obtained from large-scale genome-wide association studies. Data on longevity beyond the 90
resultsRisk factors associated with a lower odds of longevity included the following: genetic liability to type 2 diabetes (OR 0.88; 95% CI: 0.84;0.92), genetically predicted systolic and diastolic blood pressure (per 1-mmHg increase: 0.96; 0.94;0.97 and 0.95; 0.93;0.97), body mass index (per 1-SD increase: 0.80; 0.74;0.86), low-density lipoprotein cholesterol (per 1-SD increase: 0.75; 0.65;0.86) and smoking initiation (0.75; 0.66;0.85). Genetically increased high-density lipoprotein cholesterol (per 1-SD increase: 1.23; 1.08;1.41) and educational level (per 1-SD increase: 1.64; 1.45;1.86) were associated with a higher odds of longevity. Fasting glucose and other lifestyle factors were not significantly associated with longevity.
conclusionMost of the Life's Simple 7 modifiable risk factors are causally related to longevity. Prevention strategies should focus on modifying these risk factors and reducing education inequalities to improve cardiovascular health and longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.