ArticleEuropean heart journal. Cardiovascular Imaging2021
Pericoronary adipose tissue computed tomography attenuation distinguishes different stages of coronary artery disease: a cross-sectional study.
Article in European heart journal. Cardiovascular Imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed.
- Diagnosis of coronary artery disease in patients with type 2 diabetes mellitus based on computed tomography and pericoronary adipose tissue radiomics: a retrospective cross-sectional study.Cardiovascular diabetology · 2023Trial
- Review
- Coronary microvascular dysfunction: a narrative review.Cardiovascular diagnosis and therapy · 2026Review
- Association of Relative Pericoronary Adipose Tissue Attenuation with Coronary Artery Calcification Severity.Medicina (Kaunas, Lithuania) · 2026Article
- Pericoronary adipose tissue as a biomarker of coronary atherosclerosis and cardiovascular risk in rheumatoid arthritis.Rheumatology (Oxford, England) · 2026Observational
- Computed Tomography-Based Radiomics Provides New Insights Into Associations Between Pericoronary Fat Characteristics and Low-Density Lipoprotein Cholesterol.Reviews in cardiovascular medicine · 2026Article
- Design and rationale of the WARRIOR ancillary study for coronary CT angiographic analysis.American heart journal · 2026Article
- Coronary Plaque Vulnerability and Pericoronary Adipose Tissue Inflammation: Emerging Insights from Advanced CT Imaging.Medicina (Kaunas, Lithuania) · 2026Review
- Article
- A new insight on imaging characteristics of pericoronary adipose tissue for cardiovascular risk.Cardiovascular ultrasound · 2026Review
- Artificial Intelligence in Coronary Plaque Characterization: Clinical Implications, Evidence Gaps, and Future Directions.Journal of clinical medicine · 2026Review
- Non-enhanced CT-based radiomics signature of epicardial adipose tissue for screening coronary heart disease.Frontiers in cardiovascular medicine · 2026Article
- "Pericoronary adipose tissue attenuation as a marker of global coronary inflammation rather than lesion-specific risk".Frontiers in cardiovascular medicine · 2026Article
- Predicting major adverse cardiovascular events in diabetic and non-diabetic patients with coronary artery disease: visual models integrating multi-parametric coronary computed tomography angiography and pericoronary adipose tissue radiomics.Frontiers in cardiovascular medicine · 2026Article
- Pericoronary Adipose Tissue Imaging on Coronary CT Angiography: From Fat Attenuation Index to Radiomic Risk Phenotyping.BioMed research international · 2026Review
- Non-invasive diagnostic value of pericoronary fat attenuation index for identifying culprit lesions in acute coronary syndrome.European journal of radiology open · 2025Article
- Epicardial fat thickness predicts severe coronary artery disease and high mortality risk among ST-elevation myocardial infarction patients.Echo research and practice · 2025Article
- Article
- Computed tomography-based assessment of pericoronary adipose tissue in cardiovascular diseases: Diagnostic and prognostic implications.World journal of radiology · 2025Review
- Impact of pericoronary adipose tissue attenuation on clinical outcomes after percutaneous coronary intervention.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
aimsVascular inflammation inhibits local adipogenesis in pericoronary adipose tissue (PCAT) and this can be detected on coronary computed tomography angiography (CCTA) as an increase in CT attenuation of PCAT surrounding the proximal right coronary artery (RCA). In this cross-sectional study, we assessed the utility of PCAT CT attenuation as an imaging biomarker of coronary inflammation in distinguishing different stages of coronary artery disease (CAD). METHODS AND
resultsSixty patients with acute myocardial infarction (MI) were prospectively recruited to undergo CCTA within 48 h of admission, prior to invasive angiography. These participants were matched to patients with stable CAD (n = 60) and controls with no CAD (n = 60) by age, gender, BMI, risk factors, medications, and CT tube voltage. PCAT attenuation around the proximal RCA was quantified per-patient using semi-automated software. Patients with MI had a higher PCAT attenuation (-82.3 ± 5.5 HU) compared with patients with stable CAD (-90.6 ± 5.7 HU, P < 0.001) and controls (-95.8 ± 6.2 HU, P < 0.001). PCAT attenuation was significantly increased in stable CAD patients over controls (P = 0.01). The association of PCAT attenuation with stage of CAD was independent of age, gender, cardiovascular risk factors, epicardial adipose tissue volume, and CCTA-derived quantitative plaque burden. No interaction was observed for clinical presentation (MI vs. stable CAD) and plaque burden on PCAT attenuation.
conclusionPCAT CT attenuation as a quantitative measure of global coronary inflammation independently distinguishes patients with MI vs. stable CAD vs. no CAD. Future studies should assess whether this imaging biomarker can track patient responses to therapies in different stages of CAD.
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