ArticleNature metabolism2020
Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice.
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Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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94 citing papers in PubMed, 147 citations in OpenAlex.
- Lactylation at the metabolic-epigenetic interface in cardiovascular diseases: context-dependent mechanisms and translational roadmap.Journal of advanced research · 2026Review
- Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart.Science advances · 2026Article
- Ginsenoside RK3 attenuates isoproterenol-induced heart failure in mice through AMPK/Sirt1/PGC-1α pathway activation.Journal of ginseng research · 2026Article
- The roles of free-fatty acid receptors in the pathophysiology of renal disorders.The Journal of pharmacology and experimental therapeutics · 2026Review
- Metabolic inflexibility across heart failure phenotypes: mechanisms and type-specific therapeutic implications.Apoptosis : an international journal on programmed cell death · 2026Review
- Ketogenic diet, cardiometabolic diseases and aging.Journal of geriatric cardiology : JGC · 2026Article
- [3-Npj imaging · 2026Article
- Defects in auxiliary fuel oxidation and mitochondrial pyruvate transport mark transition to overt heart failure in Tgαq*44 mice.Journal of translational medicine · 2026Article
- MSDC-0160, a novel clinical-stage mitochondrial pyruvate carrier inhibitor, suppresses osteoclast differentiation and alleviates type 2 diabetes-related bone loss.Journal of translational medicine · 2026Article
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- FAP PET identifies earlycardiac molecular changesinduced by doxorubicin chemotherapy.JCI insight · 2025Article
- HuoXue QianYang QuTan recipe attenuates myocardial hypertrophy in obese hypertensive rats by regulating MPC1/MCT4 mediated pyruvate-lactate metabolic axis.Chinese medicine · 2025Article
- Ketogenic diet strategy in patients with sepsis: a multicentre prospective randomised interventional trial protocol.BMJ open · 2025Article
- Review
- Targeting mitochondrial transporters and metabolic reprogramming for disease treatment.Journal of translational medicine · 2025Review
- The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the Heart Failure Association of the ESC.European journal of heart failure · 2025Review
- The fate of pyruvate dictates cell growth by modulating cellular redox potential.bioRxiv : the preprint server for biology · 2025Article
- High-fat intake during lactation ameliorates cardiac fatty acid metabolic disorders and dysfunction in mouse offspring undergoing prenatal poly (I:C) stimulation.Acta pharmacologica Sinica · 2025Article
- The Heart Has Intrinsic Ketogenic Capacity that Mediates NADCirculation research · 2025Article
- Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 5 institutions in 2 countries.
Kyle S McCommisDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA. kyle.mccommis@health.slu.edu.ORCID http://orcid.org/0000-0003-2381-1589
Attila KovacsDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Carla J WeinheimerDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Trevor M ShewDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Timothy R KovesDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Olga R IlkayevaDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-9779-0883
Dakota R KammDepartment of Biochemistry & Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, USA.
Kelly D PylesDepartment of Biochemistry & Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, USA.
M Todd KingLaboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD, USA.
Richard L VeechLaboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD, USA.
Brian J DeBoschDepartments of Pediatrics and Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-9924-7921
Deborah M MuoioDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0003-3760-9277
Richard W GrossDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-2262-9443
Brian N FinckDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Washington University in St. Louis · USDuke University · USNational Institute on Alcohol Abuse and Alcoholism · USSaint Louis University · USSaint Louis University · ES
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Michael Benjamin Major · 2013 to 2026
$27.1MRole of Carnitine Acetyltransferase in Mitochondrial and Metabolic FunctionR01DK089312 · NIDDK · DUKE UNIVERSITY · PI DEBORAH M MUOIO · 2010 to 2026
$7.8MTARGETING THE MITOCHONDRIAL PYRUVATE CARRIER TO TREAT NONALCOHOLIC STEATOHEPATITISR01DK104735 · NIDDK · WASHINGTON UNIVERSITY · PI FINCK, BRIAN N · 2015 to 2025
$7.1MProbing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing HeartR01HL128349 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUOIO, DEBORAH M · 2016 to 2024
$6.1MNOVEL LIPID 2ND MESSENGERS REGULATING BIOENERGETICS AND SIGNALING IN HUMAN MYOCARDIUMR01HL133178 · NHLBI · WASHINGTON UNIVERSITY · PI GROSS, RICHARD W · 2016 to 2024
$3.8MTreating secondary cardiomyopathies by mimicking the adaptive hepatic glucose fasting responseR01HL147968 · NHLBI · WASHINGTON UNIVERSITY · PI DEBOSCH, BRIAN JESSE · 2020 to 2024
$3.2MNovel insulin-sensitizing NASH/diabetes drugs.R42DK121652 · NIDDK · BIOIO, LLC · PI FINCK, BRIAN N, PETERSON, TIMOTHY R · 2019 to 2022
$1.7MLeveraging glucose transport and the adaptive fasting response to modulate hepatic metabolismR01DK126622 · NIDDK · WASHINGTON UNIVERSITY · PI DEBOSCH, BRIAN JESSE · 2021 to 2024
$1.7MLIPIN 1 AND CARDIAC METABOLISM IN THE CONTEXT OF LIPID OVERLOADR01HL119225 · NHLBI · WASHINGTON UNIVERSITY · PI FINCK, BRIAN N · 2014 to 2017
$1.5MImportance and Regulation of Cardiac Mitochondrial Pyruvate TransportR00HL136658 · NHLBI · SAINT LOUIS UNIVERSITY · PI MCCOMMIS, KYLE S · 2019 to 2021
$747kNCATS NIH HHS UL1 TR002345NCCIH NIH HHS R21 AT010520NHLBI NIH HHS K99 HL136658NHLBI NIH HHS R00 HL136658NHLBI NIH HHS R01 HL119225NHLBI NIH HHS R01 HL128349NHLBI NIH HHS R01 HL133178NHLBI NIH HHS R01 HL147968NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK089312NIDDK NIH HHS R01 DK104735NIDDK NIH HHS R01 DK126622NIDDK NIH HHS R42 DK121652NIDDK NIH HHS R56 DK115764NIH HHS S10 OD028597
Abstract
The myocardium is metabolically flexible; however, impaired flexibility is associated with cardiac dysfunction in conditions including diabetes and heart failure. The mitochondrial pyruvate carrier (MPC) complex, composed of MPC1 and MPC2, is required for pyruvate import into the mitochondria. Here we show that MPC1 and MPC2 expression is downregulated in failing human and mouse hearts. Mice with cardiac-specific deletion of Mpc2 (CS-MPC2
Indexed as
AnimalsAnion Transport ProteinsCitric Acid CycleDiet, KetogenicDown-RegulationFastingHeart FailureHumansKetone BodiesLipid MetabolismMetabolomicsMiceMice, Inbred C57BLMice, KnockoutMitochondria, HeartMitochondrial Membrane Transport ProteinsAnion Transport ProteinsKetone BodiesMitochondrial Membrane Transport ProteinsMPC2 pyruvate carrier protein, mousePyruvic Acid
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