ArticleNature metabolism2020
Mitochondrial pyruvate carriers are required for myocardial stress adaptation.
Erratum issuedOpen access · greenAbstract read
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Article in Nature metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 95 papers.
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95citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
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Who cites it
95 citing papers in PubMed, 142 citations in OpenAlex.
- Loss of ATP-Dependent Citrate Lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling.Circulation · 2026Article
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- Sodium-glucose Co-transporter 2 (SGLT2) inhibitor dapagliflozin acutely activates cardiomyocyte HIF-1α signaling via succinate, a signaling metabolite.Journal of pharmacological sciences · 2026Article
- The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases.Exploration (Beijing, China) · 2026Review
- Myocardial fibrosis and glycolysis: a bibliometric study and visualization analysis (2000-2024).Journal of translational medicine · 2026Review
- Defects in auxiliary fuel oxidation and mitochondrial pyruvate transport mark transition to overt heart failure in Tgαq*44 mice.Journal of translational medicine · 2026Article
- Genetic deletion of ASIC3 alters left ventricular remodeling and autonomic function after myocardial infarction in mice.Physiological reports · 2026Article
- SLC25A39 identified as a key regulator of hepatocellular carcinoma progression through the mitochondrial ROS-cytochrome c-caspase signaling axis.Cellular & molecular biology letters · 2025Article
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- HuoXue QianYang QuTan recipe attenuates myocardial hypertrophy in obese hypertensive rats by regulating MPC1/MCT4 mediated pyruvate-lactate metabolic axis.Chinese medicine · 2025Article
- Ketogenic diet strategy in patients with sepsis: a multicentre prospective randomised interventional trial protocol.BMJ open · 2025Article
- Metabolic regulation for the treatment of ischemic heart disease with stem cells and extracellular vesicles.NPJ cardiovascular health · 2025Review
- Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets.Nature reviews. Cardiology · 2025Review
- Reprogramming of Mitochondrial and Cellular Energy Metabolism in Fibroblasts and Cardiomyocytes: Mechanisms and Therapeutic Strategies in Cardiac Fibrosis.Journal of cardiovascular translational research · 2025Review
- Genetic Deletion of ASIC3 Alters Left Ventricular Remodeling and Autonomic Function After Myocardial Infarction in Mice.bioRxiv : the preprint server for biology · 2025Article
- The fate of pyruvate dictates cell growth by modulating cellular redox potential.bioRxiv : the preprint server for biology · 2025Article
- High-fat intake during lactation ameliorates cardiac fatty acid metabolic disorders and dysfunction in mouse offspring undergoing prenatal poly (I:C) stimulation.Acta pharmacologica Sinica · 2025Article
- Oral Sulforaphane Intervention Protects Against Diabetic Cardiomyopathy in db/db Mice: Focus on Cardiac Lipotoxicity and Substrate Metabolism.Antioxidants (Basel, Switzerland) · 2025Article
- The Heart Has Intrinsic Ketogenic Capacity that Mediates NADCirculation research · 2025Article
- Loss of mitochondrial pyruvate transport initiates cardiac glycogen accumulation and heart failure.bioRxiv : the preprint server for biology · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
30 authors at 6 institutions in 3 countries.
Yuan ZhangFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0003-0067-2096
Paul V TaufaleleFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-8239-6533
Jesse D CochranFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-9705-5785
Isabelle Robillard-FrayneDepartment of Nutrition, Université de Montréal and Montreal Heart Institute, Montreal, Canada.
Jonas Maximilian MarxSanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA.ORCID http://orcid.org/0000-0002-7935-288X
Jamie SotoFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Adam J RauckhorstFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-4101-0075
Fariba TayyariMetabolomics Core Facility, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-5837-9231
Alvin D PewaMetabolomics Core Facility, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Lawrence R GrayFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Lynn M TeeschMetabolomics Core Facility, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Patrycja PuchalskaSanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA.
Trevor R FunariFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-1465-2590
Rose McGlauflinFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Kathy ZimmermanAbboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
William J KutschkeAbboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-9358-795X
Thomas CassierFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Shannon HitchcockFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Kevin LinFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Kevin M KatoFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-8466-7149
Jennifer L StueveFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-5037-7517
Lauren HaffFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Robert M WeissAbboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0003-1307-2647
James E CoxDepartment of Biochemistry, School of Medicine, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-5977-2350
Jared RutterDepartment of Biochemistry, School of Medicine, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-2710-9765
Eric B TaylorFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Peter A CrawfordSanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA.
E Douglas LewandowskiSanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA.ORCID http://orcid.org/0000-0002-8970-9491
Christine Des RosiersDepartment of Nutrition, Université de Montréal and Montreal Heart Institute, Montreal, Canada.
E Dale AbelFraternal Order of Eagles Diabetes Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. DRCAdmin@uiowa.edu.ORCID http://orcid.org/0000-0001-5290-0738
University of Iowa · USMontreal Heart Institute · CASanford Burnham Prebys Medical Discovery Institute · USUniversity of Minnesota · USHoward Hughes Medical Institute · USUniversity of Utah · US
Funding
Multidisciplinary Lung Research Career Development ProgramT32HL007638 · NHLBI · UNIVERSITY OF IOWA · PI WELSH, MICHAEL J., ZABNER, JOSEPH · 1986 to 2020
$16.9MProteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6MKETONE BODY METABOLISM AND INTEGRATED METABOLIC HOMEOSTASISR01DK091538 · NIDDK · WASHINGTON UNIVERSITY · PI CRAWFORD, PETER A · 2011 to 2024
$6.2MMagnetic Resonance of Cardiac C13 Flux & Metabolism RateR01HL049244 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEWANDOWSKI, E DOUGLAS · 1993 to 2018
$3.7MRegulation of Hepatic Macronutrient Metabolism by Mitochondrial Citrate TransportR01DK104998 · NIDDK · UNIVERSITY OF IOWA · PI TAYLOR, ERIC B · 2015 to 2022
$3.2MMaladaptive Expression of Metabolic Enzymes and Activity in Heart FailureR01HL132525 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI LEWANDOWSKI, E DOUGLAS · 2016 to 2019
$2.5MPropagation and Resolution of Injury in Calcific Aortic Valve DiseaseR01HL142935 · NHLBI · UNIVERSITY OF IOWA · PI WEISS, ROBERT M · 2018 to 2022
$2.3MGender Effects on Remodeling of Lipid and Sarcomere Dynamics in HypertrophyR01HL113057 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEWANDOWSKI, E DOUGLAS · 2013 to 2016
$2.2MVms1 is a Novel Protein Critical for Mitochondrial MaintenanceR00AR059190 · NIAMS · UNIVERSITY OF IOWA · PI TAYLOR, ERIC B · 2012 to 2014
$730kAgilent 6550 QTOF system for U of UtahS10OD016232 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2013 to 2013
$578kQ-ToF Mass Spectrometer for the University of Utah MS and Proteomics CoreS10OD018210 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2015 to 2015
$530kAgilent 7200 GC/Q-TOF for the University of UtahS10OD021505 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2016 to 2016
$401kNHLBI NIH HHS R01 HL049244NHLBI NIH HHS R01 HL113057NHLBI NIH HHS R01 HL132525NHLBI NIH HHS R01 HL142935NHLBI NIH HHS T32 HL007638NIAMS NIH HHS R00 AR059190NIDDK NIH HHS F32 DK101183NIDDK NIH HHS R01 DK091538NIDDK NIH HHS R01 DK104998NIDDK NIH HHS U54 DK110858NIH HHS S10 OD016232NIH HHS S10 OD018210NIH HHS S10 OD019941NIH HHS S10 OD021505
Abstract
In addition to fatty acids, glucose and lactate are important myocardial substrates under physiologic and stress conditions. They are metabolized to pyruvate, which enters mitochondria via the mitochondrial pyruvate carrier (MPC) for citric acid cycle metabolism. In the present study, we show that MPC-mediated mitochondrial pyruvate utilization is essential for the partitioning of glucose-derived cytosolic metabolic intermediates, which modulate myocardial stress adaptation. Mice with cardiomyocyte-restricted deletion of subunit 1 of MPC (cMPC1
Indexed as
Adaptation, PhysiologicalAnimalsAnion Transport ProteinsCardiomegalyCardiomyopathy, DilatedConstriction, PathologicCytosolDiet, High-FatDiet, KetogenicEchocardiographyIn Vitro TechniquesMiceMice, KnockoutMitochondria, HeartMitochondrial Membrane Transport ProteinsMyocardiumAnion Transport ProteinsMitochondrial Membrane Transport ProteinsMPC2 pyruvate carrier protein, mousePyruvic Acid
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.