Evidence map›Paper›PMID 33106677›Full record

ReviewNature neuroscience2020

Challenges and future directions for representations of functional brain organization.

Janine Bijsterbosch, Samuel J Harrison, Saad Jbabdi, Mark Woolrich, Christian Beckmann, Stephen Smith, Eugene P Duff

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Metabolism-weighted brain connectome reveals synaptic integration and vulnerability to neurodegeneration.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  20. Spacetime concordance in the primate cortex.bioRxiv : the preprint server for biology · 2025
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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Janine BijsterboschMallinckrodt Institute of Radiology, Washington University in St Louis, Saint Louis, MO, USA. Janine.Bijsterbosch@wustl.edu.ORCID http://orcid.org/0000-0002-1385-9178
Samuel J HarrisonCentre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford. John Radcliffe Hospital, Oxford, UK.ORCID http://orcid.org/0000-0002-5886-2389
Saad JbabdiCentre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford. John Radcliffe Hospital, Oxford, UK.
Mark WoolrichOxford Centre for Human Brain Activity (OHBA), Wellcome Centre for Integrative Neuroimaging, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Christian BeckmannDonders Institute and Department of Cognitive Neurosciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
Stephen SmithCentre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford. John Radcliffe Hospital, Oxford, UK.ORCID http://orcid.org/0000-0001-8166-069X
Eugene P DuffCentre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford. John Radcliffe Hospital, Oxford, UK. eugene.duff@ndcn.ox.ac.uk.ORCID http://orcid.org/0000-0001-8795-5472

Funding

Department of HealthMedical Research Council MR/L009013/1Wellcome Trust 098369/Z/12/ZWellcome Trust 106183/Z/14/ZWellcome Trust 215573/Z/19/Z
6 · The paper itself

Abstract

A key principle of brain organization is the functional integration of brain regions into interconnected networks. Functional MRI scans acquired at rest offer insights into functional integration via patterns of coherent fluctuations in spontaneous activity, known as functional connectivity. These patterns have been studied intensively and have been linked to cognition and disease. However, the field is fractionated. Diverging analysis approaches have segregated the community into research silos, limiting the replication and clinical translation of findings. A primary source of this fractionation is the diversity of approaches used to reduce complex brain data into a lower-dimensional set of features for analysis and interpretation, which we refer to as brain representations. In this Primer, we provide an overview of different brain representations, lay out the challenges that have led to the fractionation of the field and that continue to form obstacles for convergence, and propose concrete guidelines to unite the field.

Indexed as

AnimalsBrainBrain MappingHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNerve NetNeural Pathways

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.