Evidence map›Paper›PMID 33106669›Full record

ArticleNature immunology2020

Early emergence of T central memory precursors programs clonal dominance during chronic viral infection.

Simon Grassmann, Lorenz Mihatsch, Jonas Mir, Atefeh Kazeroonian, Roza Rahimi, Sophie Flommersfeld, Kilian Schober, Inge Hensel, Justin Leube, Ludwig O Pachmayr and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. The ageing immune system and its battle with viruses.The Journal of general virology · 2026
    Review
  2. Review
  3. Article
  4. Design principles of the cytotoxic CD8Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Design principles of the cytotoxic CD8bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Simon Grassmann *Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.ORCID http://orcid.org/0000-0002-8336-3418
Lorenz Mihatsch *Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.ORCID http://orcid.org/0000-0003-3835-7964
Jonas MirInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.ORCID http://orcid.org/0000-0003-2067-6289
Atefeh KazeroonianInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Roza RahimiInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Sophie FlommersfeldInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Kilian SchoberInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.ORCID http://orcid.org/0000-0001-9323-9472
Inge HenselInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Justin LeubeInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Ludwig O PachmayrInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Lorenz KretschmerInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Qin ZhangDivision of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Adrien JollyDivision of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-2609-5621
M Zeeshan ChaudhryDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.ORCID http://orcid.org/0000-0002-1372-4257
Matthias SchiemannInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Luka Cicin-SainDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Thomas HöferDivision of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-3560-8780
Dirk H BuschInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.ORCID http://orcid.org/0000-0001-8713-093X
Michael FlossdorfInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany.
Veit R BuchholzInstitute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich (TUM), Munich, Germany. veit.buchholz@tum.de.ORCID http://orcid.org/0000-0003-0441-3913

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic cytomegalovirus (CMV) infection leads to long-term maintenance of extraordinarily large CMV-specific T cell populations. The magnitude of this so-called 'memory inflation' is thought to mainly depend on antigenic stimulation during the chronic phase of infection. However, by mapping the long-term development of CD8

Indexed as

Immunologic MemoryAcute DiseaseAnimalsBiomarkersChronic DiseaseClonal EvolutionCytomegalovirusCytomegalovirus InfectionsGene Expression ProfilingHost-Pathogen InteractionsHumansImmunophenotypingMiceMuromegalovirusT-Lymphocyte SubsetsVirus DiseasesBiomarkers

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.