ArticleNature biomedical engineering2021
Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies.
Article in Nature biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 161 citations in OpenAlex.
- Chiral multimodal nanoprobes for sensing of biomarkers.Nature protocols · 2026Review
- Advances and Prospects of Chiral Plasmonic Nanomaterials in Emerging Applications.Nanomaterials (Basel, Switzerland) · 2026Review
- Magnetoelectric microrobots for spinal cord injury regeneration.Nature materials · 2026Article
- c-Jun in neurodegeneration: A key transcriptional regulator with therapeutic implications.Molecular therapy. Nucleic acids · 2026Review
- Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Design, Mechanisms, and Applications of DNA-Mediated Dynamically Reconfigurable Plasmonic Gold Nanostructures.Small methods · 2026Review
- Stimuli-Responsive Materials for Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Electrical-gain-assisted circularly polarized photodetection based on chiral plasmonic metamaterials.Light, science & applications · 2025Article
- Molecular Stress Response of Mitochondria during Electrostimulation Evoking Stem Cell Differentiation Revealed by Fluorescence Imaging Combined with SERS Spectra.ACS measurement science au · 2025Article
- Dynamic hierarchical ligand anisotropy for competing macrophage regulationBioactive materials · 2025Article
- Research status of biomaterials based on physical signals for bone injury repair.Regenerative therapy · 2025Review
- Nanoscale drug formulations for the treatment of Alzheimer's disease progression.RSC advances · 2025Review
- A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson's disease.Science advances · 2025Article
- Achiral and chiral ligands synergistically harness chiral self-assembly of inorganics.Science advances · 2024Article
- Promoting Alzheimer's disease research and therapy with stem cell technology.Stem cell research & therapy · 2024Review
- Multicomponent chiral plasmonic hybrid nanomaterials: recent advances in synthesis and applications.Nanoscale advances · 2024Review
- Improved Neural Inductivity of Size-Controlled 3D Human Embryonic Stem Cells Using Magnetic Nanoparticles.Biomaterials research · 2024Article
- DNA-Based Gold Nanoparticle Assemblies: From Structure Constructions to Sensing Applications.Sensors (Basel, Switzerland) · 2023Review
- Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut-brain axis.Nature aging · 2023Article
- Disturbing cytoskeleton by engineered nanomaterials for enhanced cancer therapeutics.Bioactive materials · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biological effects of circularly polarized light on living cells are considered to be negligibly weak. Here, we show that the differentiation of neural stem cells into neurons can be accelerated by circularly polarized photons when DNA-bridged chiral assemblies of gold nanoparticles are entangled with the cells' cytoskeletal fibres. By using cell-culture experiments and plasmonic-force calculations, we demonstrate that the nanoparticle assemblies exert a circularly-polarized-light-dependent force on the cytoskeleton, and that the light-induced periodic mechanical deformation of actin nanofibres with a frequency of 50 Hz stimulates the differentiation of neural stem cells into the neuronal phenotype. When implanted in the hippocampus of a mouse model of Alzheimer's disease, neural stem cells illuminated following a polarity-optimized protocol reduced the formation of amyloid plaques by more than 70%. Our findings suggest that circularly polarized light can guide cellular development for biomedical use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.