SynthesisJournal of human genetics2021
Association of an IGHV3-66 gene variant with Kawasaki disease.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of human genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Importance of Fostering International Collaboration for Optimal Outcomes of Kawasaki Disease Worldwide: A Science Advisory From the American Heart Association.Journal of the American Heart Association · 2026Guideline
- Etiology Model of Kawasaki Disease and Multisystem Inflammatory Syndromes: Mast Cell Activation.Current issues in molecular biology · 2026Article
- Potential Mechanisms and Hypotheses for Pathogenic Microorganisms Triggering Kawasaki Disease.Clinical reviews in allergy & immunology · 2025Review
- Genotyping of selected germline adaptive immune system loci using short-read sequencing data.Genome research · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- An unbiased comparison of immunoglobulin sequence aligners.Briefings in bioinformatics · 2024Article
- The etiologies of Kawasaki disease.The Journal of clinical investigation · 2024Review
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Article
- The mechanism underlying B-cell developmental dysfunction in Kawasaki disease based on single-cell transcriptomic sequencing.Frontiers in immunology · 2024Article
- Widespread impact of immunoglobulin V-gene allelic polymorphisms on antibody reactivity.Cell reports · 2023Article
- Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire.Nature communications · 2023Article
- Widespread impact of immunoglobulin V gene allelic polymorphisms on antibody reactivity.bioRxiv : the preprint server for biology · 2023Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- ImmunoTyper-SR: A computational approach for genotyping immunoglobulin heavy chain variable genes using short-read data.Cell systems · 2022Article
- Exploration of Potential Biomarker Genes and Pathways in Kawasaki Disease: An IntegratedFrontiers in genetics · 2022Article
- Mechanisms of Immune Dysregulation in COVID-19 Are Different From SARS and MERS: A Perspective in Context of Kawasaki Disease and MIS-C.Frontiers in pediatrics · 2022Review
- Profiling genes encoding the adaptive immune receptor repertoire with gAIRR Suite.Frontiers in immunology · 2022Article
- Hygiene Hypothesis as the Etiology of Kawasaki Disease: Dysregulation of Early B Cell Development.International journal of molecular sciences · 2021Review
- Germline polymorphisms and alternative splicing of human immunoglobulin light chain genes.iScience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 18 institutions in 4 countries.
Todd A Johnson *Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Yoichi Mashimo *Department of Public Health, Chiba University Graduate School of Medicine, Chiba, Chiba, 260-8670, Japan.
Jer-Yuarn Wu *Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan. jywu@ibms.sinica.edu.tw.
Dankyu Yoon *Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Osong, 28160, Korea.ORCID http://orcid.org/0000-0003-3409-2399
Akira HataDepartment of Public Health, Chiba University Graduate School of Medicine, Chiba, Chiba, 260-8670, Japan.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.ORCID http://orcid.org/0000-0002-0095-2322
Atsushi TakahashiLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Tatsuhiko TsunodaLaboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.ORCID http://orcid.org/0000-0002-5439-7918
Kouichi OzakiLaboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Toshihiro TanakaLaboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.ORCID http://orcid.org/0000-0001-6201-9784
Kaoru ItoLaboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.ORCID http://orcid.org/0000-0003-1843-773X
Hiroyuki SuzukiDepartment of Pediatrics, Wakayama Medical University, Wakayama, Wakayama, 641-8509, Japan.
Hiromichi HamadaDepartment of Pediatrics, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Chiba, 276-8524, Japan.
Tohru KobayashiDepartment of Management and Strategy, Clinical Research Center, National Center for Child Health and Development, Tokyo, 157-8535, Japan.
Toshiro HaraFukuoka Children's Hospital, Fukuoka, Fukuoka, 813-0017, Japan.
Chien-Hsiun ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Yi-Ching LeeInstitute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan.ORCID http://orcid.org/0000-0002-7734-5619
Yi-Min LiuInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Li-Ching ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Chun-Ping ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Young-Mi HongDepartment of Pediatrics, Ewha Womans University College of Medicine, Seoul, 07985, Korea.
Gi-Young JangDepartment of Pediatrics, Korea University Ansan Hospital, Ansan, 15355, Korea.
Sin-Weon YunDepartment of Pediatrics, Chung-Ang University Hospital, Seoul, 06973, Korea.
Jeong-Jin YuDepartment of Pediatrics, Asan Medical Center, Seoul, 05505, Korea.
Kyung-Yil LeeDepartment of Pediatrics, Daejeon St. Mary's Hospital, Daejeon, 34943, Korea.
Jae-Jung KimAsan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, 05505, Korea.
Taesung ParkDepartment of Statistics, Seoul National University, Seoul, 08826, Korea.
Korean Kawasaki Disease Genetics Consortium, Taiwan Kawasaki Disease Genetics Consortium, Taiwan Pediatric ID Alliance, Japan Kawasaki Disease Genome Consortium
Jong-Keuk LeeAsan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, 05505, Korea. cookie_jklee@hotmail.com.ORCID http://orcid.org/0000-0003-1125-4017
Yuan-Tsong ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan. chen0010@ibms.sinica.edu.tw.
Yoshihiro OnouchiDepartment of Public Health, Chiba University Graduate School of Medicine, Chiba, Chiba, 260-8670, Japan. onouchy@chiba-u.jp.ORCID http://orcid.org/0000-0003-1267-5913
Institute of Biomedical Sciences, Academia Sinica · TWRIKEN Center for Integrative Medical Sciences · JPChiba University · JPTokyo Medical and Dental University · JPUlsan College · KRAsan Medical Center · KRChung-Ang University Hospital · KREwha Womans University · KRFukuoka Children's Hospital and Medical Center for Infectious Diseases · JPInstitute of Cellular and Organismic Biology, Academia Sinica · TWKorea National Institute of Health · KRKorea University · KRNational Center For Child Health and Development · JPNational Cerebral and Cardiovascular Center · JPSeoul National University · KRThe Catholic University of Korea Daejeon St. Mary's Hospital · KRTokyo Women's Medical University · JPWakayama Medical University · JP
Funding
Japan Agency for Medical Research and Development (AMED) JP18ek0410039Ministry of Health and Welfare (Ministry of Health, Welfare and Family Affairs) HI15C1575
Abstract
In a meta-analysis of three GWAS for susceptibility to Kawasaki disease (KD) conducted in Japan, Korea, and Taiwan and follow-up studies with a total of 11,265 subjects (3428 cases and 7837 controls), a significantly associated SNV in the immunoglobulin heavy variable gene (IGHV) cluster in 14q33.32 was identified (rs4774175; OR = 1.20, P = 6.0 × 10
Indexed as
Genes, Immunoglobulin Heavy ChainGenome-Wide Association StudyAdultAllelesB-LymphocytesComputer SimulationDatasets as TopicFollow-Up StudiesGene Expression RegulationGenetic Predisposition to DiseaseHigh-Throughput Nucleotide SequencingHumansJapanLeukocytesLinkage DisequilibriumModels, Genetic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.