ArticleScientific reports2020
Human amniotic membrane plug to promote failed macular hole closure.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Amniotic membrane transplantation for macular holes: decoding the optimal approach-inlay or overlay?International ophthalmology · 2025Pooled it
- Anatomical and Functional Outcomes of Platelet-Rich Plasma-Assisted Surgery for Full-Thickness Macular Holes: A Retrospective Real-World Cohort Study.Journal of clinical medicine · 2026Article
- Corneal stromal lenticule covering technique combined with intraocular tamponade for the treatment of recurrent macular holes and macular hole retinal detachments.BMC ophthalmology · 2025Article
- Enhancing Internal Limiting Membrane Inverted Flap Outcomes With Amniotic Solution for Chronic and Large Macular Holes.Retina (Philadelphia, Pa.) · 2025Article
- Amniotic membrane transplantation promotes retinal hole closure in a rabbit model.Scientific reports · 2025Article
- Refractory macular hole surgery with amniotic membrane transplant functional assessment.International journal of retina and vitreous · 2025Article
- Human amniotic membrane graft with viscodissection and intraoperative OCT for macular hole repair.American journal of ophthalmology case reports · 2025Article
- Amniotic Membrane Transplantation for Wound Healing, Tissue Regeneration and Immune Modulation.Stem cell reviews and reports · 2025Review
- Anatomical and Functional Outcomes of Human-Amniotic Membrane Graft in Refractory Macular Hole Cases.Vision (Basel, Switzerland) · 2025Article
- Management of traumatic macular hole and retinal detachment using amniotic membrane transplantation: A case report.American journal of ophthalmology case reports · 2025Article
- Outcomes of amniotic membrane transplant for refractory macular hole - an optical coherence tomography and autofluorescence long-term study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Subretinal Amniotic Membrane Transplantation in a Porcine Model of Retinal Hole.Investigative ophthalmology & visual science · 2024Article
- Biological ultrathin amniotic membrane flap to close refractory macular holes associated with high myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Human Amniotic Membrane: A Seal for Complex Retinal Detachments.Turkish journal of ophthalmology · 2024Article
- Safety and efficacy of human amniotic membrane plug transplantation in cases of macular hole. A scoping review.International journal of retina and vitreous · 2024Article
- Temporal Changes in the Retinal Pigment Epithelium-Bruch's Membrane Complex Thickness After Autologous Retinal Transplantation in Myopic Eyes.Investigative ophthalmology & visual science · 2024Article
- Platelet concentrates in macular hole surgery. A journey through the labyrinth of terminology, preparation, and application: a comprehensive review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Review
- Amniotic membrane transplantation: structural and biological properties, tissue preparation, application and clinical indications.Eye (London, England) · 2024Review
- Visualization of surgical maneuvers using intraoperative real-time volumetric optical coherence tomography.Biomedical optics express · 2023Article
- The developments in amniotic membrane transplantation in glaucoma and vitreoretinal procedures.International ophthalmology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The failed macular hole is a full-thickness defect involving the fovea that fails to close despite 1 or more surgeries. While many surgical options have been proposed to manage it, none of these guarantee complete anatomical success and satisfactory visual recovery. We report postoperative outcomes on 36 patients affected by failed macular hole, treated with a human amniotic membrane plug transplant. Follow-ups were performed with a standard ophthalmological examination and with advanced multimodal diagnostic imaging. Anatomical closure was achieved at 3 months in all patients. Mean best-corrected visual acuity improved statistically significantly at 6 months (p < 0.05). Through microperimetric tests, we assessed a partial recovery of the macular sensitivity on the edges of the plug. Analyzing SD-OCT images, we reported a tissutal ingrowth above the plug, and its segmentation into layers, mimicking normal retinal architecture. OCT-Angiography images non invasively analysed the retinal parafoveal capillary microvasculature; the elaboration of Adaptive Optics images showed the presence of photoreceptors at the edges of the plug. This work demonstrates not only the complete anatomical success of our technique, but also remarkable functional results, and opens the door to a greater understanding of modifications induced by the presence of a human amniotic membrane plug.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.