ArticleScientific reports2020
Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Influence of Intravenous Norepinephrine Administration on Melatonin Plasma Concentration in Awake and Anaesthetised Healthy Adult Volunteers.Journal of pineal research · 2026Article
- Remimazolam-induced anesthesia does not affect circadian rhythms significantly in mice.Scientific reports · 2025Article
- Multiomics integration unveils photoperiodic plasticity in the molecular rhythms of marine phytoplankton.The Plant cell · 2025Article
- Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCNCommunications biology · 2024Article
- Circadian Mechanisms in Brain Fluid Biology.Circulation research · 2024Review
- Effects of volatile anesthetics on circadian rhythm in mice: a comparative study of sevoflurane, desflurane, and isoflurane.Journal of anesthesia · 2024Article
- A retrospect and outlook on the neuroprotective effects of anesthetics in the era of endovascular therapy.Frontiers in neuroscience · 2023Review
- In focus in HCB.Histochemistry and cell biology · 2022Article
- Effects of general anesthesia on behavioral circadian rhythms and clock-gene expression in the suprachiasmatic nucleus in rats.Histochemistry and cell biology · 2022Article
- Differences in recovery processes of circadian oscillators in various tissues after sevoflurane treatmentBiochemistry and biophysics reports · 2022Article
- Role of circadian rhythms in pathogenesis of acute CNS injuries: Insights from experimental studies.Experimental neurology · 2022Review
- Progress in Research on the Effect of Melatonin on Postoperative Cognitive Dysfunction in Older Patients.Frontiers in aging neuroscience · 2022Review
- General Anaesthesia Shifts the Murine Circadian Clock in a Time-Dependant Fashion.Clocks & sleep · 2021Article
- Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.PloS one · 2021Article
- Rest-activity rhythmicity as digital biomarkers of postoperative recovery and complications in children.Digital healthArticle
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Desflurane is one of the most frequently used inhalational anesthetics in clinical practice. A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this effect with desflurane. In the present study, we examined the rest/activity rhythm of mice by counting the number of running wheel rotations, and we found that desflurane anesthesia caused a phase shift in the circadian rhythm that was dependent on the time of day of anesthesia. We also found that desflurane anesthesia altered the relative mRNA expression of four major clock genes (Per2, Bmal, Clock, and Cry1) in the suprachiasmatic nucleus (SCN). These results are important for elucidating the effects of desflurane on the SCN, which is the master clock for the mammalian circadian rhythm. Further studies on the relationship between anesthesia and circadian rhythm may lead to the prevention and treatment of postoperative complications related to circadian rhythms.
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