ArticleNature communications2020
Differential reinforcement encoding along the hippocampal long axis helps resolve the explore-exploit dilemma.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Neurobehavioral differences in value-based decision making between people with cocaine use disorder and controls.Experimental and clinical psychopharmacology · 2026Article
- Article
- Prefrontal Default Mode Network Interactions with Posterior Hippocampus during Exploration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mapping hippocampal-cerebellar functional connectivity across the human adult lifespan.Communications biology · 2025Article
- Spatial navigation strategy in older adults: Preference or ability?Psychology and aging · 2025Article
- Striatal arbitration between choice strategies guides few-shot adaptation.Nature communications · 2025Article
- Effects of childhood maltreatment and major depressive disorder on functional connectivity in hippocampal subregions.Brain imaging and behavior · 2024Article
- Reward-based option competition in human dorsal stream and transition from stochastic exploration to exploitation in continuous space.Science advances · 2024Article
- Memory consolidation from a reinforcement learning perspective.Frontiers in computational neuroscience · 2024Article
- Search for solutions, learning, simulation, and choice processes in suicidal behavior.Wiley interdisciplinary reviews. Cognitive science · 2022Review
- From exploration to exploitation: a shifting mental mode in late life development.Trends in cognitive sciences · 2021Review
- A New Paradigm for the Study of Cognitive Flexibility in Children and Adolescents: The "Virtual House Locomotor Maze" (VHLM).Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
When making decisions, should one exploit known good options or explore potentially better alternatives? Exploration of spatially unstructured options depends on the neocortex, striatum, and amygdala. In natural environments, however, better options often cluster together, forming structured value distributions. The hippocampus binds reward information into allocentric cognitive maps to support navigation and foraging in such spaces. Here we report that human posterior hippocampus (PH) invigorates exploration while anterior hippocampus (AH) supports the transition to exploitation on a reinforcement learning task with a spatially structured reward function. These dynamics depend on differential reinforcement representations in the PH and AH. Whereas local reward prediction error signals are early and phasic in the PH tail, global value maximum signals are delayed and sustained in the AH body. AH compresses reinforcement information across episodes, updating the location and prominence of the value maximum and displaying goal cell-like ramping activity when navigating toward it.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.