Evidence map›Paper›PMID 33106429›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Harnessing

Outi Keinänen, Kimberly Fung, James M Brennan, Nicholas Zia, Matt Harris, Ellen van Dam, Colin Biggin, Amos Hedt, Jon Stoner, Paul S Donnelly and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. [Research square · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Pretargeted Trop-2 ImmunoPET for Rapid, Selective Detection of Pancreatic Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  11. Review
  12. Review
  13. Production ofFrontiers in nuclear medicine · 2025
    Article
  14. Review
  15. Examination of the PET in vivo generatorEuropean journal of nuclear medicine and molecular imaging · 2024
    Article
  16. [European journal of nuclear medicine and molecular imaging · 2024
    Article
  17. Review
  18. Review
  19. Review
  20. Exploring the PET in vivo generatorbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Outi KeinänenDepartment of Chemistry, Hunter College, The City University of New York, New York, NY 10021.ORCID 0000-0002-3939-6706
Kimberly FungDepartment of Chemistry, Hunter College, The City University of New York, New York, NY 10021.
James M BrennanDepartment of Chemistry, Hunter College, The City University of New York, New York, NY 10021.
Nicholas ZiaSchool of Chemistry and Bio21 Molecular Science Institute, University of Melbourne, Melbourne, VIC 3010, Australia.
Matt HarrisClarity Pharmaceuticals, Sydney, NSW 2042, Australia.
Ellen van DamClarity Pharmaceuticals, Sydney, NSW 2042, Australia.ORCID 0000-0001-6989-5357
Colin BigginClarity Pharmaceuticals, Sydney, NSW 2042, Australia.
Amos HedtClarity Pharmaceuticals, Sydney, NSW 2042, Australia.
Jon StonerIdaho Accelerator Center, Idaho State University, Pocatello, ID 83201.
Paul S DonnellySchool of Chemistry and Bio21 Molecular Science Institute, University of Melbourne, Melbourne, VIC 3010, Australia.ORCID 0000-0001-5373-0080
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-7065-4534
Brian M ZeglisDepartment of Chemistry, Hunter College, The City University of New York, New York, NY 10021; bz102@hunter.cuny.edu.ORCID 0000-0002-9091-744X

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Pretargeted Clinical Imaging of CA19.9 in Pancreatic CancerU01CA221046 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ZEGLIS, BRIAN MATTHEW · 2018 to 2022
$3.5M
The Clinical PET Imaging of Metastatic Breast Cancer with Site-Specifically Labeled 89Zr-TrastuzumabR01CA204167 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ULANER, GARY ALLAN · 2016 to 2020
$3.4M
Novel Reagents for Rapid and Stable Thiol-Based BioconjugationsR01CA240963 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2019 to 2023
$1.6M
SHARED INSTRUMENT: FOCUS MICROPET: CANCERS10RR020892 · NCRR · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI LARSON, STEVEN MARK · 2005 to 2005
$499k
A PET Radiotracer for Diagnostic and Theranostics Imaging in Lyme DiseaseR21EB030275 · NIBIB · HUNTER COLLEGE · PI QIU, WEIGANG, ZEGLIS, BRIAN MATTHEW · 2020 to 2021
$429k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204167NCI NIH HHS R01 CA240963NCI NIH HHS R35 CA232130NCI NIH HHS U01 CA221046NCRR NIH HHS S10 RR020892
6 · The paper itself

Abstract

Over the past decade, theranostic imaging has emerged as a powerful clinical tool in oncology for identifying patients likely to respond to targeted therapies and for monitoring the response of patients to treatment. Herein, we report a theranostic approach to pretargeted radioimmunotherapy (PRIT) based on a pair of radioisotopes of copper: positron-emitting copper-64 (

Indexed as

AnimalsAntibodiesCell Line, TumorColorectal NeoplasmsCopper RadioisotopesCycloaddition ReactionDose-Response Relationship, DrugFemaleHumansImmunoconjugatesMiceMice, NudePositron-Emission TomographyPrecision MedicineRadioimmunotherapyRadioisotopesAntibodiesCopper-64Copper-67Copper RadioisotopesImmunoconjugatesRadioisotopespositron emission tomographypretargeted radioimmunotherapypretargetingradioimmunotherapytheranostics

Identifiers

PMID33106429
PMCPMC7668034

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.