Evidence map›Paper›PMID 33106418›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Characterization of systemic genomic instability in budding yeast.

Nadia M V Sampaio, V P Ajith, Ruth A Watson, Lydia R Heasley, Parijat Chakraborty, Aline Rodrigues-Prause, Ewa P Malc, Piotr A Mieczkowski, Koodali T Nishant, Juan Lucas Argueso

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Detection of "hidden" mitotic crossovers by long-read DNA sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  7. Formation of chromosomal rearrangements inbioRxiv : the preprint server for biology · 2025
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  15. Evolution and molecular bases of reproductive isolation.Current opinion in genetics & development · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Nadia M V SampaioDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523.
V P AjithSchool of Biology, Indian Institute of Science Education and Research, 695551 Thiruvananthapuram, Trivandrum, India.ORCID 0000-0002-4457-9523
Ruth A WatsonDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523.
Lydia R HeasleyDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523.
Parijat ChakrabortySchool of Biology, Indian Institute of Science Education and Research, 695551 Thiruvananthapuram, Trivandrum, India.
Aline Rodrigues-PrauseDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523.ORCID 0000-0003-2362-6631
Ewa P MalcDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599.
Piotr A MieczkowskiDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599.ORCID 0000-0003-2418-0096
Koodali T NishantSchool of Biology, Indian Institute of Science Education and Research, 695551 Thiruvananthapuram, Trivandrum, India.ORCID 0000-0002-4342-7501
Juan Lucas ArguesoDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523; lucas.argueso@colostate.edu.ORCID 0000-0002-7157-1519
Colorado State University · USIndian Institute of Science Education and Research Thiruvananthapuram · INUniversity of North Carolina at Chapel Hill · US

Funding

MinION long-read DNA sequencer system for the analysis of structural genomic variation in yeastR35GM119788 · NIGMS · COLORADO STATE UNIVERSITY · PI ARGUESO, JUAN LUCAS · 2016 to 2025
$3.7M
Properties and Mechanisms of Punctuated Genome InstabilityK99GM134193 · NIGMS · COLORADO STATE UNIVERSITY · PI HEASLEY, LYDIA RENE · 2020 to 2022
$233k
NIGMS NIH HHS K99 GM134193NIGMS NIH HHS R35 GM119788
6 · The paper itself

Abstract

Conventional models of genome evolution are centered around the principle that mutations form independently of each other and build up slowly over time. We characterized the occurrence of bursts of genome-wide loss-of-heterozygosity (LOH) in

Indexed as

Chromosomes, FungalGenome, FungalGenomic InstabilityLoss of HeterozygosityMutationRecombination, GeneticSaccharomyces cerevisiaegenomic instabilityloss-of-heterozygositymitotic recombination

Identifiers

PMID33106418
PMCPMC7668020
OpenAlexW3094607971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.