Evidence map›Paper›PMID 33106413›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Multistep substrate binding and engagement by the AAA+ ClpXP protease.

Reuben A Saunders, Benjamin M Stinson, Tania A Baker, Robert T Sauer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Protein degradation by a component of the chaperonin-linked protease ClpP.Genes to cells : devoted to molecular & cellular mechanisms · 2024
    Review
  4. The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Reuben A SaundersDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Benjamin M StinsonDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Tania A BakerDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-0737-3411
Robert T SauerDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; bobsauer@mit.edu.ORCID 0000-0002-1719-5399

Funding

Sequence Determinants of Protein Structure and StabilityR01GM101988 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SAUER, ROBERT T · 2012 to 2019
$3.5M
NIGMS NIH HHS R01 GM101988
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adenosine TriphosphatasesAdenosine TriphosphateATPases Associated with Diverse Cellular ActivitiesCryoelectron MicroscopyEndopeptidase ClpEscherichia coliEscherichia coli ProteinsGreen Fluorescent ProteinsHydrolysisKineticsProtein FoldingSubstrate SpecificityAdenosine TriphosphatasesAdenosine TriphosphateATPases Associated with Diverse Cellular ActivitiesClpXP protease, E coliEndopeptidase ClpEscherichia coli ProteinsGreen Fluorescent ProteinsATP-dependent protein degradationfluorescence quenchingpolyphasic association kineticspolyphasic dissociation kineticsspecificity

Identifiers

PMID33106413
PMCPMC7668067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.