ArticleProceedings of the National Academy of Sciences of the United States of America2020
Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Microfluidic valves for wearable sweat analysis: a review.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Review
- Smart wearable biosensors: a transformative synergy between diagnosis and treatment of disease.RSC advances · 2026Review
- Advances and Challenges in Wearable Sensors for Health Monitoring.ACS applied materials & interfaces · 2026Review
- Biomolecular profiling for noninvasive health monitoring.Nature biotechnology · 2026Review
- Wearable technologies in clinical trials for drug development: trends and emerging opportunities.Nature reviews. Drug discovery · 2026Review
- Body Biofluids for Minimally-Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential.Advanced healthcare materials · 2026Review
- Stressomic: A wearable microfluidic biosensor for dynamic profiling of multiple stress hormones in sweat.Science advances · 2025Article
- A Wearable In-Pad Diagnostic for the Detection of Disease Biomarkers in Menstruation Blood.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Noninvasive On-Skin Biosensors for Monitoring Diabetes Mellitus.Nano-micro letters · 2025Review
- Adaptive electronics for photovoltaic, photoluminescent and photometric methods in power harvesting for wireless wearable sensors.Nature communications · 2025Article
- Transforming Healthcare: Intelligent Wearable Sensors Empowered by Smart Materials and Artificial Intelligence.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Electrophoretic digital colorimetry integrated with electrochemical sweat sensor.Science advances · 2025Article
- Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Review
- Machine Learning-Driven Innovations in Microfluidics.Biosensors · 2024Review
- Molecularly Imprinted Wearable Sensor with Paper Microfluidics for Real-Time Sweat Biomarker Analysis.ACS applied materials & interfaces · 2024Article
- Wearable Sensors for Physiological Condition and Activity Monitoring.Small science · 2024Article
- Advancements in Cortisol Detection: From Conventional Methods to Next-Generation Technologies for Enhanced Hormone Monitoring.ACS sensors · 2024Review
- Clinical Endocrinology-Time for a Reset?Journal of the Endocrine Society · 2024Article
- Wearing the Lab: Advances and Challenges in Skin-Interfaced Systems for Continuous Biochemical Sensing.Advances in biochemical engineering/biotechnology · 2024Review
Corrections and comments
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Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soft microfluidic systems that capture, store, and perform biomarker analysis of microliter volumes of sweat, in situ, as it emerges from the surface of the skin, represent an emerging class of wearable technology with powerful capabilities that complement those of traditional biophysical sensing devices. Recent work establishes applications in the real-time characterization of sweat dynamics and sweat chemistry in the context of sports performance and healthcare diagnostics. This paper presents a collection of advances in biochemical sensors and microfluidic designs that support multimodal operation in the monitoring of physiological signatures directly correlated to physical and mental stresses. These wireless, battery-free, skin-interfaced devices combine lateral flow immunoassays for cortisol, fluorometric assays for glucose and ascorbic acid (vitamin C), and digital tracking of skin galvanic responses. Systematic benchtop evaluations and field studies on human subjects highlight the key features of this platform for the continuous, noninvasive monitoring of biochemical and biophysical correlates of the stress state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.