Evidence map›Paper›PMID 33106390›Full record

ArticleNeurology2021

Isabel C Hostettler, Benjamin O'Callaghan, Enrico Bugiardini, Emer O'Connor, Jana Vandrovcova, Indran Davagnanam, Varinder Alg, Stephen Bonner, Daniel Walsh, Diederik Bulters and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Rare genetic variants inInternational journal of stroke : official journal of the International Stroke Society · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Isabel C HostettlerFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.ORCID 0000-0002-9004-2540
Benjamin O'CallaghanFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.ORCID 0000-0002-1323-6843
Enrico BugiardiniFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.ORCID 0000-0002-9709-6699
Emer O'ConnorFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.
Jana VandrovcovaFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.
Indran DavagnanamFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.ORCID 0000-0002-0363-1911
Varinder AlgFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.
Stephen BonnerFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.
Daniel WalshFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.ORCID 0000-0003-1274-3285
Diederik BultersFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.ORCID 0000-0001-9884-9050
Neil KitchenFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.
Martin M BrownFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.
Joan GrieveFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.
David J WerringFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust.
Henry HouldenFrom the Stroke Research Centre (I.C.H., V.A., M.M.B., D.J.W.), MRC Centre for Neuromuscular Diseases (B.O., E.B.), and Department of Neuromuscular Disorders (E.B., J.V.), UCL Queen Square Institute of Neurology; Neurogenetics Laboratory (I.C.H., B.O., E.O., H.H.) and Departments of Neuroradiology (I.D.) and Neurosurgery (N.K., J.G.), the National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London; Department of Anaesthesia (S.B.), the James Cook University Hospital, Middlesbrough; Department of Neurosurgery (D.W.), King's College Hospital NHS Foundation Trust, London; and Department of Neurosurgery (D.B.), University Hospital Southampton NHS Foundation Trust. h.houlden@ucl.ac.uk.
Genetics and Observational Subarachnoid Haemorrhage (GOSH) study investigators
James Cook University Hospital · GB

Funding

Department of Health
6 · The paper itself

Abstract

purposeTo understand the role of the angiopoietin-like 6 gene (

methodsIndividuals with family history of IA were recruited to the Genetic and Observational Subarachnoid Haemorrhage (GOSH) study. The

resultsWe found 6 rare

conclusionCLASSIFICATION OF EVIDENCE: This is a Class III study showing some specificity of presence of the

Indexed as

Genetic Predisposition to DiseaseAdultAgedAngiopoietin-Like Protein 6Angiopoietin-like ProteinsCase-Control StudiesFemaleHumansIntracranial AneurysmMaleMiddle AgedPedigreeSubarachnoid HemorrhageTissue BanksAngiopoietin-Like Protein 6Angiopoietin-like ProteinsANGPTL6 protein, human

Identifiers

PMID33106390
PMCPMC8105901
OpenAlexW3093869410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.