Evidence map›Paper›PMID 33106292›Full record

ArticleInfection and immunity2021

Exogenous Reproductive Hormones nor Candida albicans Colonization Alter the Near Neutral Mouse Vaginal pH.

Jian Miao, Hubertine M E Willems, Brian M Peters

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Impact of pH andProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Loss of theMicrobiology spectrum · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jian Miao *Pharmaceutical Sciences Program, College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Hubertine M E Willems *Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Brian M PetersDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA brian.peters@uthsc.edu.ORCID 0000-0002-0445-2077
University of Tennessee Health Science Center · US

Funding

Candidalysin: a key mediator of Candida vaginitis immunopathologyR01AI134796 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Brian M Peters · 2018 to 2026
$2.9M
Targeted and forward genetic approaches to decipher the pathogenesis of symptomatic vulvovaginal candidiasisR21AI141829 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PETERS, BRIAN M · 2019 to 2020
$418k
NIAID NIH HHS R01 AI134796NIAID NIH HHS R21 AI141829
6 · The paper itself

Abstract

While human vaginal pH in childbearing-age women is conclusively acidic, the mouse vaginal pH is reported as being near neutral. However, this information appears to be somewhat anecdotal with respect to vulvovaginal candidiasis, as such claims in the literature frequently lack citations of studies that specifically address this physiological factor. Given the disparate pH between mice and humans, the role of exogenous hormones and colonization by the fungal pathogen

Indexed as

AdultAnimalsCandidiasis, VulvovaginalDisease Models, AnimalEstradiolFemaleHumansHydrogen-Ion ConcentrationMiceMice, Inbred C57BLMice, Inbred DBAVaginaEstradiolCandidamousemucosapHvaginavaginitisvulvovaginalVVC

Identifiers

PMID33106292
PMCPMC7822140
OpenAlexW3094618889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.