Evidence map›Paper›PMID 33106247›Full record

ArticleGenetics2020

Yeast Nucleolin Nsr1 Impedes Replication and Elevates Genome Instability at an Actively Transcribed Guanine-Rich G4 DNA-Forming Sequence.

Shivani Singh, Alexandra Berroyer, Minseon Kim, Nayun Kim

Open access · hybridAbstract read
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shivani SinghDepartment of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston, Houston, Texas 77030.
Alexandra BerroyerDepartment of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston, Houston, Texas 77030.
Minseon KimDepartment of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston, Houston, Texas 77030.ORCID 0000-0001-5299-0008
Nayun KimDepartment of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston, Houston, Texas 77030 nayun.kim@uth.tmc.edu.
The University of Texas Health Science Center at Houston · USThe University of Texas MD Anderson Cancer Center · US

Funding

RNA decay and processing activities of the RNA exosomeR01GM099790 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VAN HOOF, AMBRO · 2012 to 2020
$2.6M
G-Quadruplex forming sequence motifs and genome instabilityR01GM116007 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KIM, NAYUN · 2016 to 2020
$1.7M
NIGMS NIH HHS R01 GM099790NIGMS NIH HHS R01 GM116007
6 · The paper itself

Abstract

A significant increase in genome instability is associated with the conformational shift of a guanine-run-containing DNA strand into the four-stranded G-quadruplex (G4) DNA. The mechanism underlying the recombination and genome rearrangements following the formation of G4 DNA

Indexed as

DNA ReplicationGenomic InstabilityG-QuadruplexesAmino Acid MotifsNuclear ProteinsRNA-Binding ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription, GeneticNSR1 protein, S cerevisiaeNuclear ProteinsRNA-Binding ProteinsSaccharomyces cerevisiae ProteinsG4 DNAgenome instabilitynucleolinreplication

Identifiers

PMID33106247
PMCPMC7768239
OpenAlexW3094562941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.