ArticleeLife2020
Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis suggests that tACS improves cognition in healthy, aging, and psychiatric populations.Science translational medicine · 2023Pooled it
- Phase-Specific Dual-Site Beta Transcranial Alternating Current Stimulation Differentially Influences Functional Connectivity Associated With Motor Inhibition Performance.Human brain mapping · 2026Article
- Lateral frontopolar theta-band activity supports flexible switching between emotion regulation strategies.Scientific reports · 2025Article
- Phase-lagged tACS between executive and default mode networks modulates working memory.Scientific reports · 2025Article
- Neural Mechanisms Underlying Robust Target Selection in Response to Microstimulation of the Oculomotor System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- What can neurofeedback and transcranial alternating current stimulation reveal about cross-frequency coupling?Frontiers in neuroscience · 2025Article
- Multifocal transcranial electrical stimulation to enhance cognitive functions: a systematic review.Frontiers in neuroscience · 2025Review
- Designing interventions to scaffold emotional awareness, beliefs and action tendencies.PloS one · 2025Article
- Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex.Nature communications · 2023Article
- Mental Activity as the Bridge between Neural Biomarkers and Symptoms of Psychiatric Illness.Clinical EEG and neuroscience · 2023Article
- Social avoidance behavior modulates motivational responses to social reward-threat conflict signals: A preliminary fMRI study.Cognitive, affective & behavioral neuroscience · 2023Article
- Reward-Based Decision-Making Engages Distinct Modes of Cross-Frequency Coupling.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Get to grips with motivation: Slipping and gripping movements are biased by approach-avoidance context.Frontiers in psychology · 2022Article
- Working Memory and Transcranial-Alternating Current Stimulation-State of the Art: Findings, Missing, and Challenges.Frontiers in psychology · 2022Review
- Targeting neural oscillations with transcranial alternating current stimulation.Brain research · 2021Review
- Causal role of cross-frequency coupling in distinct components of cognitive control.Progress in neurobiology · 2021Article
- Defensive freezing and its relation to approach-avoidance decision-making under threat.Scientific reports · 2021Article
- Effects of Transcranial Alternating Current Stimulation and Neurofeedback on Alpha (EEG) Dynamics: A Review.Frontiers in human neuroscience · 2021Review
- Approach-Avoidance Decisions Under Threat: The Role of Autonomic Psychophysiological States.Frontiers in neuroscience · 2021Article
- Phase-Amplitude Coupling, Mental Health and Cognition: Implications for Adolescence.Frontiers in human neuroscience · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Control over emotional action tendencies is essential for everyday interactions. This cognitive function fails occasionally during socially challenging situations, and systematically in social psychopathologies. We delivered dual-site phase-coupled brain stimulation to facilitate theta-gamma phase-amplitude coupling between frontal regions known to implement that form of control, while neuropsychologically healthy human male participants were challenged to control their automatic action tendencies in a social-emotional approach/avoidance-task. Participants had increased control over their emotional action tendencies, depending on the relative phase and dose of the intervention. Concurrently measured fMRI effects of task and stimulation indicated that the intervention improved control by increasing the efficacy of anterior prefrontal inhibition over the sensorimotor cortex. This enhancement of emotional action control provides causal evidence for phase-amplitude coupling mechanisms guiding action selection during emotional-action control. Generally, the finding illustrates the potential of physiologically-grounded interventions aimed at reducing neural noise in cerebral circuits where communication relies on phase-amplitude coupling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.