ArticleBMC genomics2020
Transcriptomic analysis reveals the GRAS family genes respond to gibberellin in Salvia miltiorrhiza hairy roots.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- bHLH130 mediates gibberellin signaling to regulate tanshinone biosynthesis inActa pharmaceutica Sinica. B · 2026Article
- Recent Advances in Transcription Factor-Mediated Regulation of Salvianolic Acid Biosynthesis inPlants (Basel, Switzerland) · 2026Review
- Identification of single nucleotide polymorphisms and candidate genes associated with fiber content in sweetpotato (Ipomoea batatas (L.) Lam.) through a genome-wide association study.BMC plant biology · 2025Article
- Gibberellin-Induced Transcription FactorMolecules (Basel, Switzerland) · 2024Article
- A near-complete assembly of the Houttuynia cordata genome provides insights into the regulatory mechanism of flavonoid biosynthesis in Yuxingcao.Plant communications · 2024Article
- Biosynthesis and signal transduction of plant growth regulators and their effects on bioactive compound production in Salvia miltiorrhiza (Danshen).Chinese medicine · 2024Review
- Genome-Wide Identification of theInternational journal of molecular sciences · 2024Article
- Transcriptome sequencing and metabolome analysis reveal the molecular mechanism of Salvia miltiorrhiza in response to drought stress.BMC plant biology · 2024Article
- Spatiotemporal and Transcriptional Characterization on Tanshinone Initial Synthesis inInternational journal of molecular sciences · 2022Article
- The Expression Profiles of the Salvia miltiorrhiza 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase 4 Gene and Its Influence on the Biosynthesis of TanshinonesMolecules (Basel, Switzerland) · 2022Article
- Transcriptome and HPLC Analysis Reveal the Regulatory Mechanisms of Aurantio-Obtusin in Space Environment-InducedInternational journal of environmental research and public health · 2022Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSalvia miltiorrhiza is one of the most important traditional Chinese medicinal plants with high medicinal value. Gibberellins are growth-promoting phytohormones that regulate numerous growth and developmental processes in plants. However, their role on the secondary metabolism regulation has not been investigated.
resultsIn this study, we found that gibberellic acid (GA) can promote hairy roots growth and increase the contents of tanshinones and phenolic acids. Transcriptomic sequencing revealed that many genes involved in the secondary metabolism pathway were the GA-responsive. After further analysis of GA signaling pathway genes, which their expression profiles have significantly changed, it was found that the GRAS transcription factor family had a significant response to GA. We identified 35 SmGRAS genes in S. miltiorrhiza, which can be divided into 10 subfamilies. Thereafter, members of the same subfamily showed similar conserved motifs and gene structures, suggesting possible conserved functions.
conclusionsMost SmGRAS genes were significantly responsive to GA, indicating that they may play an important role in the GA signaling pathway, also participating in the GA regulation of root growth and secondary metabolism in S. miltiorrhiza.
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