Evidence map›Paper›PMID 33106031›Full record

ArticleCirculation2021

A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function.

Kelsey M Pinckard, Vikram K Shettigar, Katherine R Wright, Eaman Abay, Lisa A Baer, Pablo Vidal, Revati S Dewal, Devleena Das, Silvia Duarte-Sanmiguel, Diego Hernández-Saavedra and 17 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 2 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 2 syntheses or guidelines pooled it, 150 citations in OpenAlex.

  1. New Mediators in the Crosstalk between Different Adipose Tissues.International journal of molecular sciences · 2024
    Pooled it
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  15. Advances in Adipose Tissue Biology.Endocrine reviews · 2026
    Review
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  20. Exercise, Exerkines, and Sarcopenia.Diabetes & metabolism journal · 2026
    Review

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 5 institutions in 2 countries.

Kelsey M Pinckard *Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Vikram K Shettigar *Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Katherine R WrightDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Eaman AbayDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Lisa A BaerDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Pablo VidalDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Revati S DewalDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Devleena DasDepartment of Biomedical Engineering (D.D., S.D.-S., D.G.P.), The Ohio State University, Columbus.
Silvia Duarte-SanmiguelDepartment of Biomedical Engineering (D.D., S.D.-S., D.G.P.), The Ohio State University, Columbus.
Diego Hernández-SaavedraDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Peter J ArtsDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Adam C LehnigDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Valerie BussbergBERG, Framingham, MA (V.B., N.R.N., M.A.K.).
Niven R NarainBERG, Framingham, MA (V.B., N.R.N., M.A.K.).
Michael A KiebishBERG, Framingham, MA (V.B., N.R.N., M.A.K.).
Fanchao YiTranslational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, FL (F.Y., L.M.S., B.H.G., S.R.S., R.E.P., E.D.L., P.M.C.).
Lauren M SparksTranslational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, FL (F.Y., L.M.S., B.H.G., S.R.S., R.E.P., E.D.L., P.M.C.).
Bret H GoodpasterTranslational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, FL (F.Y., L.M.S., B.H.G., S.R.S., R.E.P., E.D.L., P.M.C.).
Steven R SmithTranslational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, FL (F.Y., L.M.S., B.H.G., S.R.S., R.E.P., E.D.L., P.M.C.).
Richard E PratleyTranslational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, FL (F.Y., L.M.S., B.H.G., S.R.S., R.E.P., E.D.L., P.M.C.).
E Douglas LewandowskiDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Subha V RamanDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Loren E WoldDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Daniel Gallego-PerezDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Paul M CoenTranslational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, FL (F.Y., L.M.S., B.H.G., S.R.S., R.E.P., E.D.L., P.M.C.).
Mark T Ziolo *Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
Kristin I Stanford *Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (K.M.P., V.K.S., K.R.W., E.A., L.A.B., P.V., R.S.D., D.H.-S., P.J.A., A.C.L., E.D.L., S.V.R., L.E.W., D.G.P., M.T.Z., K.I.S.).
The Ohio State University Wexner Medical Center · USTranslational Research Institute for Metabolism and Diabetes · USFramingham State University · USThe Ohio State University · USDiscovery Institute · US

Funding

BAT as a therapeutic for the metabolic and cardiac dysfunction with senescence.R01AG060542 · NIA · OHIO STATE UNIVERSITY · PI COEN, PAUL MARTIN, STANFORD, KRISTIN I · 2019 to 2023
$3.0M
Novel nanoscale approaches to whole tissue reprogrammingDP2EB028110 · NIBIB · OHIO STATE UNIVERSITY · PI GALLEGO-PEREZ, DANIEL · 2018 to 2022
$2.7M
Training To Provide the Knowledge, Skills, and Culture To the Next Generation of Cardiovascular ScientistsT32HL134616 · NHLBI · OHIO STATE UNIVERSITY · PI Brandon J Biesiadecki, Jill A Rafael-Fortney · 2017 to 2026
$2.6M
A Novel Role for Brown Adipose Tissue Enhance Heart Function and MetabolismR01HL138738 · NHLBI · OHIO STATE UNIVERSITY · PI STANFORD, KRISTIN I · 2017 to 2021
$2.3M
Non-Viral Modulation of Cutaneous Tissue Plasticity as a Therapy for DiabetesDP1DK126199 · NIDDK · OHIO STATE UNIVERSITY · PI GALLEGO-PEREZ, DANIEL · 2020 to 2020
$737k
American Heart Association-American Stroke Association 17CSA33610078-STANFORDNHLBI NIH HHS R01 HL138738NHLBI NIH HHS T32 HL134616NIA NIH HHS R01 AG060542NIBIB NIH HHS DP2 EB028110NIDDK NIH HHS DP1 DK126199
6 · The paper itself

Abstract

backgroundBrown adipose tissue (BAT) is an important tissue for thermogenesis, making it a potential target to decrease the risks of obesity, type 2 diabetes, and cardiovascular disease, and recent studies have also identified BAT as an endocrine organ. Although BAT has been implicated to be protective in cardiovascular disease, to this point there are no studies that identify a direct role for BAT to mediate cardiac function.

methodsTo determine the role of BAT on cardiac function, we utilized a model of BAT transplantation. We then performed lipidomics and identified an increase in the lipokine 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME). We utilized a mouse model with sustained overexpression of 12,13-diHOME and investigated the role of 12,13-diHOME in a nitric oxide synthase type 1 deficient (NOS1

resultsHere, we determined that transplantation of BAT (+BAT) improves cardiac function via the release of the lipokine 12,13-diHOME. Sustained overexpression of 12,13-diHOME using tissue nanotransfection negated the deleterious effects of a high-fat diet on cardiac function and remodeling, and acute injection of 12,13-diHOME increased cardiac hemodynamics via direct effects on the cardiomyocyte. Furthermore, incubation of cardiomyocytes with 12,13-diHOME increased mitochondrial respiration. The effects of 12,13-diHOME were absent in

conclusionsOur results identify an endocrine role for BAT to enhance cardiac function that is mediated by regulation of calcium cycling via 12,13-diHOME and NOS1.

Indexed as

Adipose Tissue, BrownAgedAnimalsCells, CulturedCohort StudiesFemaleHeart FailureHumansLipidomicsMaleMiceMice, Inbred C57BLMiddle AgedOleic AcidsPhysical Conditioning, Animal12,13-dihydroxyoctadecenoic acidOleic Acids1213-diHOMEbrown adipose tissue (BAT)cardiac functionexerciselipokinesNOS1

Identifiers

PMID33106031
PMCPMC7856257
OpenAlexW3094633340

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.