Evidence map›Paper›PMID 33105937›Full record

ArticleZhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology2020

[Liver failure and glucocorticoid resistance].

X Wang, H R Xu, Y D Wang, C Shen, C Y Zhao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. [Risk Factors and Etiology of Pulmonary Fungal Infection in Patients With End-Stage Liver Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

X WangDepartment of Infectious Diseases, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China; Baodi District Hospital of Traditional Chinese Medicine in Tianjin, Tianjin 301800, China.
H R XuDepartment of Infectious Diseases, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China; Huaihe Hospital of Henan University, Kaifeng 475000, China.
Y D WangDepartment of Infectious Diseases, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
C ShenDepartment of Infectious Diseases, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
C Y ZhaoDepartment of Infectious Diseases, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main pathogenesis of liver failure is immune damage and uncontrolled inflammatory response. Glucocorticoids have strong immunosuppressive and anti-inflammatory effects, and are considered to be useful for the treatment of liver failure. However, the results of many clinical studies have shown that the application of glucocorticoids in patients with liver failure cannot effectively improve the prognosis, but instead increases the chance of infection and endangers life. Provided that, it seems reasonable to assume that glucocorticoid resistance exists in patients with liver failure. This article analyzes the mechanism by which P-glycoprotein reverses glucocorticoid transport, intracellular glucocorticoid signaling pathway dysfunction and related gene mutations when the inflammatory response is uncontrolled. In addition, we also evaluated the sensitivity of glucocorticoids in patients with liver failure, so as to provide theoretical basis for efficacy and medication timing.

Indexed as

Drug ResistanceLiver FailureGlucocorticoidsHumansReceptors, GlucocorticoidSignal TransductionGlucocorticoidsReceptors, GlucocorticoidGlucocorticoidsInflammatory reactionLiver failureSignal pathway

Identifiers

PMID33105937
PMCPMC12769957
OpenAlexW3094583113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.