Evidence map›Paper›PMID 33105840›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

Attenuation of Oxidative Stress by Cannabinoids and Cannabis Extracts in Differentiated Neuronal Cells.

Aruna Raja, Soha Ahmadi, Fernanda de Costa, Nan Li, Kagan Kerman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 51 citations in OpenAlex.

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  9. The effects of cannabidiol and its main metabolites on human neural stem cells.Experimental biology and medicine (Maywood, N.J.) · 2025
    Article
  10. Prospects in the Use ofBiotech (Basel (Switzerland)) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aruna RajaDepartment of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, M1C 1A4 ON, Canada.
Soha AhmadiDepartment of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, M1C 1A4 ON, Canada.
Fernanda de CostaLupos Biotechnology Inc., 221 Morrish Road, Toronto, M1C 1E9 ON, Canada.
Nan LiLupos Biotechnology Inc., 221 Morrish Road, Toronto, M1C 1E9 ON, Canada.
Kagan KermanDepartment of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, M1C 1A4 ON, Canada.
University of Toronto · CA

Funding

Canada Foundation for Innovation 35272Canada Research Chairs 950-231116Mitacs Accelerate post-doctoral fellowshipNatural Sciences and Engineering Research Council of Canada 3655Ontario Centres of Excellence 31094Ontario Ministry of Research, Innovation and Science 35272
6 · The paper itself

Abstract

In this proof-of-concept study, the antioxidant activity of phytocannabinoids, namely cannabidiol (CBD) and Δ9- tetrahydrocannabinol (THC), were investigated using an in vitro system of differentiated human neuronal SY-SH5Y cells. The oxidative stress was induced by hydrogen peroxide, as reactive oxygen species (ROS). Alzheimer's disease (AD)-like pathological conditions were mimicked in vitro by treating the differentiated neuronal cells with amyloid-β

Indexed as

amyloid-βantioxidantcannabinoidCBDoxidative stressreactive oxygen speciesSY-SH5Y cellsTHC

Identifiers

PMID33105840
PMCPMC7690570
OpenAlexW3093840722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.