Evidence map›Paper›PMID 33105830›Full record

ReviewMolecules (Basel, Switzerland)2020

Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders.

Roghayeh Shahbazi, Hamed Yasavoli-Sharahi, Nawal Alsadi, Nafissa Ismail, Chantal Matar

3 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05164692 nacompletednot on this map

Application of LiveSpo Navax in Treatment of Acute Respiratory Disease in Children Infected With Respiratory Syncytial Virus

TypeinterventionalSponsorNational Children's Hospital, VietnamRan2020 to 2021Enrolled100ConditionsAcute Respiratory Tract InfectionsArmsLiveSpo Navax, 0.9% NaCl physiological saline
NCT05378022 nacompletednot on this map

Application of LiveSpo Navax in Treatment of Acute Respiratory Disease in Children Infected With Influenza Virus

TypeinterventionalSponsorNational Children's Hospital, VietnamRan2020 to 2022Enrolled70ConditionsAcute Respiratory Tract InfectionsArmsLiveSpo Navax, 0.9% NaCl physiological saline
NCT06148194 nacompletednot on this mapstarted 2024, after this paper: background citation

Efficacy of Physiological Saline and Probiotics (LiveSpo Navax) in Preventing Respiratory Diseases in Children Aged 2-5, in Son Tay Province, Hanoi

TypeinterventionalSponsorAnabio R&DRan2024 to 2024Enrolled600ConditionsRespiratory Disease, Respiratory Infections in ChildrenArms0.9% NaCl physiological saline, Probiotic 1, Probiotic 2
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
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  6. Review
  7. The Therapeutic Administration ofMicroorganisms · 2026
    Article
  8. Review
  9. Article
  10. The therapeutic potential ofFrontiers in microbiology · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. The Mystery of CertainMicroorganisms · 2025
    Review
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  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Roghayeh ShahbaziCellular and Molecular Medicine Department, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Hamed Yasavoli-SharahiCellular and Molecular Medicine Department, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Nawal AlsadiCellular and Molecular Medicine Department, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Nafissa IsmailSchool of Psychology, Faculty of Social Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Chantal MatarCellular and Molecular Medicine Department, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
University of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation is a biological response to the activation of the immune system by various infectious or non-infectious agents, which may lead to tissue damage and various diseases. Gut commensal bacteria maintain a symbiotic relationship with the host and display a critical function in the homeostasis of the host immune system. Disturbance to the gut microbiota leads to immune dysfunction both locally and at distant sites, which causes inflammatory conditions not only in the intestine but also in the other organs such as lungs and brain, and may induce a disease state. Probiotics are well known to reinforce immunity and counteract inflammation by restoring symbiosis within the gut microbiota. As a result, probiotics protect against various diseases, including respiratory infections and neuroinflammatory disorders. A growing body of research supports the beneficial role of probiotics in lung and mental health through modulating the gut-lung and gut-brain axes. In the current paper, we discuss the potential role of probiotics in the treatment of viral respiratory infections, including the COVID-19 disease, as major public health crisis in 2020, and influenza virus infection, as well as treatment of neurological disorders like multiple sclerosis and other mental illnesses.

Indexed as

BetacoronavirusBrainCoronavirus InfectionsCOVID-19Gastrointestinal MicrobiomeGastrointestinal TractHumansImmunomodulationInfluenza, HumanLungMental DisordersMicrobial ConsortiaMultiple SclerosisOrthomyxoviridaePandemicsPneumonia, ViralCOVID-19gut-brain axisgut-lung axisgut microbiotaimmunomodulationinfluenza virus infectionmultiple sclerosisneuroinflammationprobioticsviral respiratory infections

Identifiers

PMID33105830
PMCPMC7660077
OpenAlexW3093478002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.