Evidence map›Paper›PMID 33105679›Full record

ArticleGenes2020

Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease Do Not Associate with Measures of Sub-Clinical Atherosclerosis: Results from the IMPROVE Study.

Luigi Castaldo, Federica Laguzzi, Rona J Strawbridge, Damiano Baldassarre, Fabrizio Veglia, Lorenzo Vigo, Elena Tremoli, Ulf de Faire, Per Eriksson, Andries J Smit and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. International journal of molecular sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 6 countries.

Luigi CastaldoDepartment of Clinical Medicine and Surgery, University of Naples "Federico II", 80138 Naples, Italy.ORCID 0000-0001-6883-9396
Federica LaguzziUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden.
Rona J StrawbridgeMental Health and Wellbeing, Institute of Health and Wellbeing, University of Glasgow, Glasgow G12-8QQ, UK.ORCID 0000-0001-8506-3585
Damiano BaldassarreCentro Cardiologico Monzino, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Via Parea 4, 20138 Milan, Italy.
Fabrizio VegliaCentro Cardiologico Monzino, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Via Parea 4, 20138 Milan, Italy.ORCID 0000-0002-9378-8874
Lorenzo VigoCentro Cardiologico Monzino, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Via Parea 4, 20138 Milan, Italy.
Elena TremoliCentro Cardiologico Monzino, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Via Parea 4, 20138 Milan, Italy.
Ulf de FaireUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden.
Per ErikssonCardiovascular Medicine, Department of Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden.
Andries J SmitDepartment of Medicine, Division of vascular medicine University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Jiri AubrechtTakeda Pharmaceuticals International Co., Cambridge, 02139 MA, USA.
Karin LeanderUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden.
Matteo PirroUnit of Internal Medicine, Department of Medicine, University of Perugia, 06123 Perugia PG, Italy.
Philippe GiralAssistance Publique-Hopitaux de Paris; Service Endocrinologie-Metabolisme, Groupe Hôpitalier Pitie-Salpetriere, Unités de Prévention Cardiovasculaire, 75013 Paris, France.
Alberto RitieniDepartment of Pharmacy, University of Naples "Federico II", 80138 Naples, Italy.ORCID 0000-0003-0314-8839
Giovanni Di MinnoDepartment of Clinical Medicine and Surgery, University of Naples "Federico II", 80138 Naples, Italy.
Anders MälarstigCardiovascular Medicine, Department of Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden.ORCID 0000-0003-2608-1358
Bruna GiganteCardiovascular Medicine, Department of Medicine, Karolinska Institutet, Box 210, 171 77 Stockholm, Sweden.
Karolinska Institutet · SECentro Cardiologico Monzino · ITUniversity of Naples Federico II · ITAssistance Publique – Hôpitaux de Paris · FRTakeda (United States) · USUniversity Medical Center Groningen · NLUniversity of Milan · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) and atherosclerosis-related cardiovascular diseases (CVD) share common metabolic pathways. We explored the association between three NAFLD-associated single nucleotide polymorphisms (SNPs) rs738409, rs10401969, and rs1260326 with sub-clinical atherosclerosis estimated by the carotid intima-media thickness (c-IMT) and the inter-adventitia common carotid artery diameter (ICCAD) in patients free from clinically overt NAFLD and CVD. The study population is the IMPROVE, a multicenter European study (

Indexed as

AgedAlanine TransaminaseAmino Acid SubstitutionAtherosclerosisCarotid ArteriesCarotid Intima-Media ThicknessFemaleGenetic Association StudiesHumansMaleNon-alcoholic Fatty Liver DiseasePolymorphism, Single NucleotideAlanine Transaminasealanine aminotransferase and genetic association studycarotid intima-media thicknessnon-alcoholic fatty liver disease

Identifiers

PMID33105679
PMCPMC7690395
OpenAlexW3094121618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.