Evidence map›Paper›PMID 33105568›Full record

ArticleInternational journal of molecular sciences2020

Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors.

Hannah Rochow, Monika Jung, Sabine Weickmann, Bernhard Ralla, Carsten Stephan, Sefer Elezkurtaj, Ergin Kilic, Zhongwei Zhao, Klaus Jung, Annika Fendler and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Hannah RochowDepartment of Urology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Monika JungDepartment of Urology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Sabine WeickmannDepartment of Urology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Bernhard RallaDepartment of Urology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Carsten StephanDepartment of Urology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Sefer ElezkurtajInstitute of Pathology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Ergin KilicInstitute of Pathology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Zhongwei ZhaoDepartment of Urology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Klaus JungDepartment of Urology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Annika FendlerDepartment of Urology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Antonia FranzDepartment of Urology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEMax Delbrück Center · DEQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As new biomarkers, circular RNAs (circRNAs) have been largely unexplored in prostate cancer (PCa). Using an integrative approach, we aimed to evaluate the potential of circRNAs and their linear transcripts (linRNAs) to act as (i) diagnostic biomarkers for differentiation between normal and tumor tissue and (ii) prognostic biomarkers for the prediction of biochemical recurrence (BCR) after radical prostatectomy. In a first step, eight circRNAs (circ

Indexed as

AgedBiomarkers, TumorGene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm Recurrence, LocalOligonucleotide Array Sequence AnalysisPrognosisProstatectomyProstatic NeoplasmsReal-Time Polymerase Chain ReactionReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionRNA, CircularRNA, Long NoncodingBiomarkers, TumorNEAT1 long non-coding RNA, humanRNA, CircularRNA, Long Noncodingbiochemical recurrencecircular RNAs and linear counterpartsdiagnostic and prognostic tissue biomarkersidentificationimproved predictive accuracy by RNA signaturemicroarrayprostate cancervalidation and differential expression of circular RNAs

Identifiers

PMID33105568
PMCPMC7672590
OpenAlexW3093536214

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.