ArticleAnalytical chemistry2020
Ion Mobility Spectrometry with High Ion Utilization Efficiency Using Traveling Wave-Based Structures for Lossless Ion Manipulations.
Article in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Selectivity Beyond Mass: Real-Time Isomer Separation Using SLIM IMS Coupled to PTR-MS.Journal of mass spectrometry : JMS · 2026Article
- Characterization of Gas-Phase Native(-like) Proteins Using Structures for Lossless Ion Manipulations.Analytical chemistry · 2026Article
- Improving Peak Capacity in Glycan Ion Mobility Separations through Traveling Wave-Based Ion Heating.Journal of the American Society for Mass Spectrometry · 2026Article
- Ion confinement and separation using asymmetric electrodynamic fields in structures for lossless ion manipulations.Rapid communications in mass spectrometry : RCM · 2024Article
- Mobility Selective Ion Soft-Landing and Characterization Enabled Using Structures for Lossless Ion Manipulation.Analytical chemistry · 2024Article
- Accumulation of Large Ion Populations with High Ion Densities and Effects Due to Space Charge in Traveling Wave-Based Structures for Lossless Ion Manipulations (SLIM) IMS-MS.Journal of the American Society for Mass Spectrometry · 2024Article
- New Approach for the Identification of Isobaric and Isomeric Metabolites.Analytical chemistry · 2023Article
- Multistage Ion Mobility Spectrometry Combined with Infrared Spectroscopy for Glycan Analysis.Journal of the American Society for Mass Spectrometry · 2023Article
- Identification ofThe Analyst · 2022Article
- Toward High-Throughput Cryogenic IR Fingerprinting of Mobility-Separated Glycan Isomers.ACS measurement science au · 2021Article
- A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies.The Analyst · 2021Article
- Masked Multiplexed Separations to Enhance Duty Cycle for Structures for Lossless Ion Manipulations.Analytical chemistry · 2021Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Ion packets introduced from gates, ion funnel traps, and other conventional ion injection mechanisms produce ion pulse widths typically around a few microseconds or less for ion mobility spectrometry (IMS)-based separations on the order of 100 milliseconds. When such ion injection techniques are coupled with ultralong path length traveling wave (TW)-based IMS separations (i.e., on the order of seconds) using structures for lossless ion manipulations (SLIMs), typically very low ion utilization efficiency is achieved for continuous ion sources [e.g., electrospray ionization (ESI)]. Even with the ability to trap and accumulate much larger populations of ions than being conventionally feasible over longer time periods in SLIM devices, the subsequent long separations lead to overall low ion utilization. Here, we report the use of a highly flexible SLIM arrangement, enabling concurrent ion accumulation and separation and achieving near-complete ion utilization with ESI. We characterize the ion accumulation process in SLIM, demonstrate >98% ion utilization, and show both increased signal intensities and measurement throughput. This approach is envisioned to have broad utility to applications, for example, involving the fast detection of trace chemical species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.