ArticleEnvironmental science and pollution research international2021
Effects of lead exposure on salivary glands of rats: insights into the oxidative biochemistry and glandular morphology.
Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Impact of midazolam on salivary glands: a comprehensive analysis of oxidative biochemistry, morphological changes, and salivary composition.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Particulate and gaseous air pollutants exceed WHO guideline values and have the potential to damage human health in Faisalabad, Metropolitan, Pakistan.Environmental monitoring and assessment · 2024Article
- Facilitating Nitrite-Derived S-Nitrosothiol Formation in the Upper Gastrointestinal Tract in the Therapy of Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Improvement effect of gemigliptin on salivary gland dysfunction in exogenous methylglyoxal-injected rats.Heliyon · 2024Article
- Metabolome-Wide Association Study of Multiple Plasma Metals with Serum Metabolomic Profile among Middle-to-Older-Aged Chinese Adults.Environmental science & technology · 2022Article
- Salivary Glands after Prolonged Aluminum Exposure: Proteomic Approach Underlying Biochemical and Morphological Impairments in Rats.International journal of molecular sciences · 2022Article
- Chronic exposure to lead acetate promotes changes in the alveolar bone of rats: microstructural and physical-chemical characterization.Environmental science and pollution research international · 2022Article
- Serum Indicators of Oxidative Damage from Embedded Metal Fragments in a Rat Model.Oxidative medicine and cellular longevity · 2022Article
- The Beneficial Impact of the Black Chokeberry Extract against the Oxidative Stress in the Sublingual Salivary Gland of Rats Intoxicated with Cadmium.Oxidative medicine and cellular longevity · 2021Article
- Lead-Induced Motor Dysfunction Is Associated with Oxidative Stress, Proteome Modulation, and Neurodegeneration in Motor Cortex of Rats.Oxidative medicine and cellular longevity · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the effects of lead (Pb) exposure on parotid and submandibular glands through morphological aspects as well as the systemic and salivary gland redox state. Male Wistar rats were exposed to 50 mg/kg/day of Pb-acetate or distilled water by intragastric gavage for 55 days (n = 40). Blood samples were used for lipid peroxidation (LPO), glutathione (GSH), and trolox equivalent antioxidant capacity (TEAC) assays. Samples of salivary glands were analyzed by LPO, nitrites (NO), and antioxidant capacity against peroxyl radicals (ACAP) levels. Morphometric analyses (total stromal area [TSA], total parenchyma area [TPA], total ductal area [TDA], and total acinar area [TAA]) and immunohistochemistry for cytokeratin-19 (CK-19), metallothionein I/II (MT I/II), and anti-smooth muscle actin (α-SMA) were performed. The results revealed that exposure to Pb triggered systemic oxidative stress represented by lower GSH levels and increased TBARS/TEAC ratio in blood plasma. ACAP was reduced, while NO and LPO were increased in both parotid and submandibular. The morphological analyses showed increase on MT I/II expression, reduced CK-19 expression in both glands, and α-SMA reduced the immunostaining only in the parotid glands. The morphometric analyses revealed an increase in TPA in both glands, while TAA was reduced only in submandibular glands and TDA was increased only in parotid glands. Our findings are pioneer in showing that long-term exposure to Pb is able to promote blood and glandular oxidative stress associated with cellular, morphological, and biochemical damage in both parotid and submandibular glands.
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