Evidence map›Paper›PMID 33104968›Full record

Observational studyJournal of clinical monitoring and computing2021

Dynamic tracking of microvascular hemoglobin content for continuous perfusion monitoring in the intensive care unit: pilot feasibility study.

Asher A Mendelson, Ajay Rajaram, Daniel Bainbridge, Keith St Lawrence, Tracey Bentall, Michael Sharpe, Mamadou Diop, Christopher G Ellis, Canadian Critical Care Translational Biology Group

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical monitoring and computing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Non-invasive point-of-care optical technique for continuous in vivo assessment of microcirculatory function: Application to a preclinical model of early sepsis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Asher A MendelsonDepartment of Medical Biophysics, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0003-2108-4752
Ajay RajaramDepartment of Medical Biophysics, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0002-0949-4137
Daniel BainbridgeDepartment of Anesthesia and Peri-operative Medicine, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0003-3422-788X
Keith St LawrenceDepartment of Medical Biophysics, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0001-8022-8205
Tracey BentallDivision of Critical Care, Department of Medicine, Western University, London, ON, Canada.
Michael SharpeDepartment of Anesthesia and Peri-operative Medicine, Western University, London, ON, Canada.
Mamadou DiopDepartment of Medical Biophysics, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0003-1244-7830
Christopher G EllisDepartment of Medical Biophysics, Western University, London, ON, Canada. cgellis@uwo.ca.ORCID http://orcid.org/0000-0002-7760-1846
Canadian Critical Care Translational Biology Group
Western University · CA

Funding

CIHR RN248497
6 · The paper itself

Abstract

purposeThere is a need for bedside methods to monitor oxygen delivery in the microcirculation. Near-infrared spectroscopy commonly measures tissue oxygen saturation, but does not reflect the time-dependent variability of microvascular hemoglobin content (MHC) that attempts to match oxygen supply with demand. The objective of this study is to determine the feasibility of MHC monitoring in critically ill patients using high-resolution near-infrared spectroscopy to assess perfusion in the peripheral microcirculation.

methodsProspective observational cohort of 36 patients admitted within 48 h at a tertiary intensive care unit. Perfusion was measured on the quadriceps, biceps, and/or deltoid, using the temporal change in optical density at the isosbestic wavelength of hemoglobin (798 nm). Continuous wavelet transform was applied to the hemoglobin signal to delineate frequency ranges corresponding to physiological oscillations in the cardiovascular system.

results31/36 patients had adequate signal quality for analysis, most commonly affected by motion artifacts. MHC signal demonstrates inter-subject heterogeneity in the cohort, indicated by different patterns of variability and frequency composition. Signal characteristics were concordant between muscle groups in the same patient, and correlated with systemic hemoglobin levels and oxygen saturation. Signal power was lower for patients receiving vasopressors, but not correlated with mean arterial pressure. Mechanical ventilation directly impacts MHC in peripheral tissue.

conclusionMHC can be measured continuously in the ICU with high-resolution near-infrared spectroscopy, and reflects the dynamic variability of hemoglobin distribution in the microcirculation. Results suggest this novel hemodynamic metric should be further evaluated for diagnosing microvascular dysfunction and monitoring peripheral perfusion.

Indexed as

HemoglobinsIntensive Care UnitsFeasibility StudiesHumansMicrocirculationOxygen SaturationPerfusionProspective StudiesHemoglobinsCritical careHemodynamic monitorMicrocirculationNear-infrared spectroscopyWavelet analysis

Identifiers

PMID33104968
PMCPMC7586414
OpenAlexW3094483339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.